SYNTHESIS OF A NEW PROTECTED LACTAM-BRIDGED DIPEPTIDE

被引：29

作者：

EDE, NJ

RAE, ID

HEARN, MTW

机构：

[1] MONASH UNIV,DEPT CHEM,CLAYTON,VIC 3168,AUSTRALIA

[2] MONASH UNIV,DEPT BIOCHEM,CLAYTON,VIC 3168,AUSTRALIA

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 42期

关键词：

D O I：

10.1016/S0040-4039(00)98031-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method has been developed for the synthesis of a new protected γ-lactam-bridged dipeptide. This R,S lactam has been prepared in good yield and incorporated into a peptide which is analogous to hGH (7-13) using standard solid phase peptide synthesis methodolgy. The peptide showed insulin-potentiating activity of the same order as those containing an imide in place of the lactam. © 1990.

引用

页码：6071 / 6074

页数：4

共 11 条

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[10]

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