FACILITATION OF THE INDUCTION OF LONG-TERM POTENTIATION BY GABA-B RECEPTORS

被引：266

作者：

MOTT, DD

LEWIS, DV

机构：

[1] DUKE UNIV,MED CTR,DEPT PEDIAT NEUROL,DURHAM,NC 27710

[2] DUKE UNIV,MED CTR,DEPT NEUROBIOL,DURHAM,NC 27710

来源：

SCIENCE | 1991年 / 252卷 / 5013期

关键词：

D O I：

10.1126/science.1675489

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Long-term potentiation (LTP), an in vitro model of learning, was induced in hippocampal slices by 5-hertz stimulation. During induction, gamma-aminobutyric acid A (GABA(A)) inhibition decreased, causing the N-methyl-D-aspartate receptor-mediated excitation to increase. 2-OH Saclofen, a GABA(B) receptor antagonist, prevented the reduction of inhibition, the increase of excitation, and the induction of LTP. Therefore, disinhibition caused by GABA(B) receptors is required for induction of LTP by 5-hertz stimulation. GABA(B) receptor modulation of synaptic plasticity occurs at frequencies in the range of the endogenous hippocampal theta rhythm, which has been shown to modulate LTP in vivo.

引用

页码：1718 / 1720

页数：3

共 25 条

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