RAISED RESTING ENERGY-EXPENDITURE IN PARKINSONS-DISEASE AND ITS RELATIONSHIP TO MUSCLE RIGIDITY

被引:99
作者
MARKUS, HS
COX, M
TOMKINS, AM
机构
[1] UNIV COLL & MIDDLESEX HOSP,SCH MED,DEPT NEUROL,LONDON,ENGLAND
[2] UNIV LONDON LONDON SCH HYG & TROP MED,COLL CLIN NUTR,LONDON WC1E 7HT,ENGLAND
关键词
ENERGY EXPENDITURE; MUSCLE RIGIDITY; PARKINSONS DISEASE; WEIGHT LOSS;
D O I
10.1042/cs0830199
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
1. Resting energy expenditure was measured, by indirect calorimetry, in 12 patients with Parkinson's disease and in eight healthy age-matched control subjects. In the patients with Parkinson's disease measurements were made in both the untreated state and after an injection of the dopamine agonist apomorphine (treated state). In each state muscle rigidity was recorded. 2. Resting energy expenditure was higher in patients with Parkinson's disease in both the treated and untreated states than in the control subjects. Of the patients with Parkinson's disease, seven showed no difference in resting energy expenditure between the two treatment states, whereas four showed markedly increased resting energy expenditure in the untreated state. The change in resting energy expenditure in the untreated state, as compared with the treated state, was significantly related to the development of muscle rigidity in the untreated state. 3. In Parkinson's disease, even in optimally treated patients, resting energy expenditure is raised and this may contribute to the weight loss seen in this disease. Severe muscle rigidity occurring during untreated periods results in a further increase in resting energy expenditure.
引用
收藏
页码:199 / 204
页数:6
相关论文
共 16 条
[1]  
BROUSSOLLE E, 1991, REV NEUROL, V147, P46
[2]   INCREASED RESTING ENERGY-EXPENDITURE IN CYSTIC-FIBROSIS [J].
BUCHDAHL, RM ;
COX, M ;
FULLEYLOVE, C ;
MARCHANT, JL ;
TOMKINS, AM ;
BRUETON, MJ ;
WARNER, JO .
JOURNAL OF APPLIED PHYSIOLOGY, 1988, 64 (05) :1810-1816
[3]   EFFECTS OF BETA-ADRENERGIC-BLOCKADE ON LATERAL HYPOTHALAMIC LESION-INDUCED THERMOGENESIS [J].
CORBETT, SW ;
KAUFMAN, LN ;
KEESEY, RE .
AMERICAN JOURNAL OF PHYSIOLOGY, 1983, 245 (06) :E535-E541
[4]   BODY-MASS INDEX AS A MEASURE OF BODY FATNESS - AGE-SPECIFIC AND SEX-SPECIFIC PREDICTION FORMULAS [J].
DEURENBERG, P ;
WESTSTRATE, JA ;
SEIDELL, JC .
BRITISH JOURNAL OF NUTRITION, 1991, 65 (02) :105-114
[5]  
FROMENT J, 1929, J MED LYON, V226, P377
[6]   PARKINSONISM - ONSET PROGRESSION AND MORTALITY [J].
HOEHN, MM ;
YAHR, MD .
NEUROLOGY, 1967, 17 (05) :427-&
[7]  
LAITINEN A, 1986, NEUROLOGY, V36, P393
[8]   HYPOTHALAMUS IN PARKINSON DISEASE [J].
LANGSTON, JW ;
FORNO, LS .
ANNALS OF NEUROLOGY, 1978, 3 (02) :129-133
[9]   INCREASED ENERGY-EXPENDITURE IN PARKINSONS-DISEASE [J].
LEVI, S ;
COX, M ;
LUGON, M ;
HODKINSON, M ;
TOMKINS, A .
BRITISH MEDICAL JOURNAL, 1990, 301 (6763) :1256-1257
[10]  
MARKUS HS, IN PRESS P NUTR SOC