HLA ANTIGENS IN TLINGIT INDIANS WITH RHEUMATOID-ARTHRITIS

被引：51

作者：

NELSON, JL

BOYER, G

TEMPLIN, D

LANIER, A

BARRINGTON, R

NISPEROS, B

SMITH, A

MICKELSON, E

HANSEN, JA

机构：

[1] ALASKA NATIVE MED CTR,RHEUMATOL,ANCHORAGE,AK

[2] UNIV WASHINGTON,DEPT MED,DIV ONCOL,SEATTLE,WA 98195

来源：

TISSUE ANTIGENS | 1992年 / 40卷 / 02期

关键词：

HLA; RHEUMATOID ARTHRITIS; TLINGIT INDIANS;

D O I：

10.1111/j.1399-0039.1992.tb01960.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

HLA-DR4 has been described in association with rheumatoid arthritis (RA) in multiple populations. We have studied HLA antigens in Alaskan Tlingit Indians. HLA-DR4 was decreased in the RA group (n = 32) compared with controls (n = 62) (6% vs 21% p = 0.07). The predominant DR4 allele observed was DRB1*0403 (Dw13.1). The most striking observation in these studies was a marked predominance of the DRB1*1402 allele encoding Dw16 (DRw14). This allele was present in 91% of RA cases, but was also highly prevalent in controls (80%, OR = 2.4 p = 0.20). DRB1*1402 only was observed in 47% of cases and 31% of controls. The DRB3*0101 (DRw52), and the DQA*0501 and DQB*0301 alleles encoding a subset of DQw3 were associated with DRB1*1402 in cases and in controls. HLA-Bw62 was increased in RA cases (28%) compared with controls (8%) (OR = 4.5, p = 0.01, corrected p = ns).

引用

页码：57 / 63

页数：7

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