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The influence of prolonged antidepressant treatment on the changes in cyclic AMP accumulation induced by excitatory amino acids in rat cerebral cortical slices

被引：21
作者：
Pilc, A
Legutko, B
机构：
来源：
NEUROREPORT | 1995年 / 7卷 / 01期
关键词：
metabotropic glutamate receptors; cyclic AM accumulation; ibotenate; glutamate; prolonged imipramine treatment; prolonged electroconvulsive shock treatment;
D O I：
10.1097/00001756-199512000-00020
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
WE investigated the effect of prolonged electroconvulsive shock (ECS) or imipramine treatment on cyclic AMP accumulation induced by ibotenate and glutamate in rat cerebral cortical slices. Prolonged imipramine or electroconvulsive shock treatment attenuated the ibotenate-induced increase in cyclic AMP accumulation and inhibited the synergistic interaction between ibotenate and noradrenaline; the glutamate-mediated inhibition of forskolin-stimulated cyclic AMP accumulation was not modified Our results indicate that multiple effects of excitatory amino acids on cyclic AMP accumulation are modified differently by antidepressant treatment.
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页码：85 / 88
页数：4
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