A COMPARATIVE-EVALUATION OF THE SENSITIVITY OF 7 ANTI-HEPATITIS-C VIRUS SCREENING-TESTS

被引：21

作者：

COUROUCE, AM

BARIN, F

BOTTE, C

LUNEL, F

MAISONNEUVE, P

MANIEZ, M

TREPO, C

机构：

[1] HOP BRETONNEAU,DEPT VIROL,TOURS,FRANCE

[2] CTR TRANSFUS SANGUINE,NANCY,FRANCE

[3] HOP LA PITIE SALPETRIERE,DEPT VIROL,PARIS,FRANCE

[4] CTR TRANSFUS SANGUINE,VERSAILLES,FRANCE

[5] CTR TRANSFUS SANGUINE,LILLE,FRANCE

[6] INSERM,U271,LYON,FRANCE

来源：

VOX SANGUINIS | 1995年 / 69卷 / 03期

关键词：

D O I：

10.1111/j.1423-0410.1995.tb02597.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The sensitivity of the most recent generation of anti-hepatitis C virus (anti-HCV) screening tests from seven manufacturers was evaluated with a common panel of 530 specimens from 320 HCV-infected subjects. This panel included 221 samples from 57 seroconverters (53 pre-sere conversion negative specimens and 168 positive samples) and 309 selected specimens from 263 other HCV-infected patients of which 19% exhibited NS3 or core reactivity alone with the presence of HCV-RNA assessed by PCR. None of the seven screening tests detected all infectious and antibody-positive specimens. However, important differences were observed between these assays in the number of false-negative results, which seemed mainly due to nonreactivity of antibody to the NS3 antigen.

引用

页码：213 / 216

页数：4

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