MECHANISM AND EVOLUTION OF THE UNCOUPLING PROTEIN OF BROWN ADIPOSE-TISSUE

被引：249

作者：

KLINGENBERG, M

机构：

[1] Institut für Physikalische Biochemie, Universität München, 8000 München 2

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1990年 / 15卷 / 03期

关键词：

D O I：

10.1016/0968-0004(90)90194-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The uncoupling protein found in mitochondria from thermogenic brown adipose tissue is structurally very similar to two other mitochondrial carrier proteins transporting ADP/ATP and phosphate, respectively. Similarities are also seen with the mechanism of these carriers, which are part of a family of H+/OH--substrate anion co-transporters, further strengthening the evidence that the uncoupling protein has evolved from this family of mitochondrial carrier proteins. © 1990.

引用

页码：108 / 112

页数：5

共 32 条

[1] CARBOXYATRACTYLATE INHIBITS THE UNCOUPLING EFFECT OF FREE FATTY-ACIDS
ANDREYEV, AY
BONDAREVA, TO
DEDUKHOVA, VI
MOKHOVA, EN
SKULACHEV, VP
VOLKOV, NI
[J]. FEBS LETTERS, 1988, 226 (02) : 265 - 269
[2] THE UNCOUPLING PROTEIN FROM BROWN FAT MITOCHONDRIA IS RELATED TO THE MITOCHONDRIAL ADP ATP CARRIER - ANALYSIS OF SEQUENCE HOMOLOGIES AND OF FOLDING OF THE PROTEIN IN THE MEMBRANE
AQUILA, H
LINK, TA
KLINGENBERG, M
[J]. EMBO JOURNAL, 1985, 4 (09) : 2369 - 2376
[3] SOLUTE CARRIERS INVOLVED IN ENERGY-TRANSFER OF MITOCHONDRIA FORM A HOMOLOGOUS PROTEIN FAMILY
AQUILA, H
LINK, TA
KLINGENBERG, M
[J]. FEBS LETTERS, 1987, 212 (01) : 1 - 9
[4] THE TRANSMEMBRANE ARRANGEMENT OF THE ADP/ATP CARRIER AS ELUCIDATED BY THE LYSINE REAGENT PYRIDOXAL 5-PHOSPHATE
BOGNER, W
AQUILA, H
KLINGENBERG, M
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1986, 161 (03): : 611 - 620
[5] BOTFIELD MC, 1988, J BIOL CHEM, V263, P12909
[6] ASPARTIC ACID-96 AND ASPARTIC ACID-85 PLAY A CENTRAL ROLE IN THE FUNCTION OF BACTERIORHODOPSIN AS A PROTON PUMP
BUTT, HJ
FENDLER, K
BAMBERG, E
TITTOR, J
OESTERHELT, D
[J]. EMBO JOURNAL, 1989, 8 (06) : 1657 - 1663
[7] IN THE UNCOUPLING PROTEIN FROM BROWN ADIPOSE-TISSUE THE C-TERMINUS PROTRUDES TO THE C-SIDE OF THE MEMBRANE AS SHOWN BY TRYPTIC CLEAVAGE
ECKERSKORN, C
KLINGENBERG, M
[J]. FEBS LETTERS, 1987, 226 (01): : 166 - 170
[8] LIGHT-DRIVEN PROTONATION CHANGES OF INTERNAL ASPARTIC ACIDS OF BACTERIORHODOPSIN - AN INVESTIGATION BY STATIC AND TIME-RESOLVED INFRARED DIFFERENCE SPECTROSCOPY USING [4-C-13] ASPARTIC ACID LABELED PURPLE MEMBRANE
ENGELHARD, M
GERWERT, K
HESS, B
KREUTZ, W
SIEBERT, F
[J]. BIOCHEMISTRY, 1985, 24 (02) : 400 - 407
[9] MOLECULAR-WEIGHT AND HYDRODYNAMIC PARAMETERS OF THE ADENOSINE 5'-DIPHOSPHATE-ADENOSINE 5'-TRIPHOSPHATE CARRIER IN TRITON X-100
HACKENBERG, H
KLINGENBERG, M
[J]. BIOCHEMISTRY, 1980, 19 (03) : 548 - 555
[10] BROWN-ADIPOSE-TISSUE MITOCHONDRIA - PHOTOAFFINITY LABELING OF REGULATORY SITE OF ENERGY-DISSIPATION
HEATON, GM
WAGENVOORD, RJ
KEMP, A
NICHOLLS, DG
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1978, 82 (02): : 515 - 521

← 1 2 3 4 →