STUDIES ON THE ANTICOMPLEMENTARY ACTIVITY OF JOZANN - ANTICOMPLEMENTARY ACTIVITY OF STEROID DERIVATIVES

被引：6

作者：

EBIHARA, T ^{[1
]}

KAWAI, T ^{[1
]}

KUROYANAGI, M ^{[1
]}

FUKUSHIMA, S ^{[1
]}

UENO, A ^{[1
]}

机构：

[1] UNIV SHIZUOKA, SCH PHARMACEUT SCI, 395 YADA, SHIZUOKA 422, JAPAN

来源：

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 1991年 / 111卷 / 06期

关键词：

ANTICOMPLEMENTARY ACTIVITY; 3-BETA-HYDROXYSTIGMAST-5-EN-7-ONE; DICHROAE RADIX; STIGMASTANE; CHOLESTANE; ANDROSTANE; PREGNANE;

D O I：

10.1248/yakushi1947.111.6_299

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Methanol extracts of 53 crude drugs were tested on the anticomplementary activity. Of these, 12 samples showed the potent activity. Of these 12 samples, the extract of Jozann (Dichrome Radix) was studied on the isolation and structural elucidation of the anticomplementary constituents. As active constituents, 3-beta-hydroxystigmast-5-en-7-one was isolated and its structure was conformed by deriving this compound from beta-sitosterol. The activity of such steroid derivatives as stigmastane, cholestane, androstane and pregnane type steroids were further studied. Of these, several kinds of steroids showed the potent activity. From these experiments, the structure and activity relationship was discussed.

引用

页码：299 / 305

页数：7

共 9 条

[1] C-13 NMR-STUDIES .69. C-13 NMR-SPECTRA OF STEROIDS - SURVEY AND COMMENTARY [J].

BLUNT, JW ;

STOTHERS, JB .

ORGANIC MAGNETIC RESONANCE, 1977, 9 (08) :439-464

[2]

CUSSANS NJ, 1975, TETRAHEDRON, V31, P2719, DOI 10.1016/0040-4020(75)80338-3

[3]

FGWANG TG, 1984, IMMUNOLOGY, V51, P207

[4] STUDIES ON POLYSACCHARIDES FROM ANGELICA-ACUTILOBA .5. MOLECULAR AGGREGATION AND ATNICOMPLEMENTARY ACTIVITY OF ARABINOGALACTAN FROM ANGELICA-ACUTILOBA [J].

KIYOHARA, H ;

YAMADA, H ;

CYONG, JC ;

OTSUKA, Y .

JOURNAL OF PHARMACOBIO-DYNAMICS, 1986, 9 (04) :339-346

[5] ISOLATION AND IDENTIFICATION OF HYDRANGENOL AND UMBELLIFERONE FROM CULTURED-CELLS OF AMACHA (HYDRANGEA-MACROPHYLLA SERINGE VAR THUNBERGII MAKINO) [J].

SUZUKI, H ;

IKEDA, T ;

MATSUMOTO, T ;

NOGUCHI, M .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1977, 41 (01) :205-206

[6]

TOMODA M, 1989, CHEM PHARM BULL, V37, P3029, DOI 10.1248/cpb.37.3029

[7] RELATIONSHIP BETWEEN CHEMICAL-STRUCTURE AND ATNICOMPLEMENTARY ACTIVITY OF PLANT POLYSACCHARIDES [J].

YAMADA, H ;

NAGAI, T ;

CYONG, JC ;

OTSUKA, Y ;

TOMODA, M ;

SHIMIZU, N ;

SHIMADA, K .

CARBOHYDRATE RESEARCH, 1985, 144 (01) :101-111

[8] STUDIES ON POLYSACCHARIDES FROM ANGELICA-ACUTILOBA .1. FRACTIONATION AND BIOLOGICAL PROPERTIES OF POLYSACCHARIDES [J].

YAMADA, H ;

KIYOHARA, H ;

CYONG, JC ;

KOJIMA, Y ;

KUMAZAWA, Y ;

OTSUKA, Y .

PLANTA MEDICA, 1984, 50 (02) :163-167

[9]

YAMADA H, 1987, CHEM PHARM BULL, V35, P4851

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