THE ADSORPTION OF BOVINE SERUM-ALBUMIN BY LIPOSOMES

被引：30

作者：

LAW, SL

LO, WY

PAI, SH

TEH, GW

KOU, FY

机构：

[1] VET GEN HOSP, DEPT MED RES, PHARMACEUT RES LAB, TAIPEI, TAIWAN

[2] NATL DEF MED CTR, DEPT BIOCHEM, TAIPEI, TAIWAN

[3] COPLEY PHARMACEUT INC, COPLEY, MA 02127 USA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1986年 / 32卷 / 2-3期

关键词：

D O I：

10.1016/0378-5173(86)90184-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The absorption of bovine serum albumin on positively charged, negatively charged and neutral liposomes with different ratios of charge has been investigated. It was found that the amount absorbed at saturation was not influenced by the pH, characteristics of charge or ratio of charge. This may be due to the driving force for adsorption being dominated by hydrophobic effect.

引用

收藏

页码：237 / 241

页数：5

相关论文

共 15 条

[1]

HANAHAN DJ, 1951, J BIOL CHEM, V192, P623

[2] DETERMINATION OF PROTEIN - MODIFICATION OF LOWRY METHOD THAT GIVES A LINEAR PHOTOMETRIC RESPONSE [J].

HARTREE, EF .

ANALYTICAL BIOCHEMISTRY, 1972, 48 (02) :422-&

[3] EFFECT OF FETAL CALF SERUM AND SERUM-PROTEIN FRACTIONS ON THE UPTAKE OF LIPOSOMAL PHOSPHATIDYLCHOLINE BY RAT HEPATOCYTES IN PRIMARY MONOLAYER-CULTURE [J].

HOEKSTRA, D ;

SCHERPHOF, G .

BIOCHIMICA ET BIOPHYSICA ACTA, 1979, 551 (01) :109-121

[4]

KIMBELBERG HK, 1971, BIOCHIM BIOPHYS ACTA, V233, P805

[5] PROTEIN-LIPOSOME INTERACTIONS AND THEIR RELEVANCE TO STRUCTURE AND FUNCTION OF CELL-MEMBRANES [J].

KIMELBERG, HK .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 1976, 10 (03) :171-190

[6] EFFECT OF ALBUMIN AND METHYLATED ALBUMIN ON GLUCOSE PERMEABILITY OF LIPID-MEMBRANES [J].

KITAGAWA, T ;

INOUE, K ;

NOJIMA, S .

JOURNAL OF BIOCHEMISTRY, 1976, 79 (06) :1135-1145

[7]

KNIGHT GG, 1981, LIPOSOMES PHYSICAL S

[8] RAMAN SPECTROSCOPIC DETECTION AND EXAMINATION OF INTERACTION OF AMINO-ACIDS, POLYPEPTIDES AND PROTEINS WITH PHOSPHATIDYLCHOLINE LAMELLAR STRUCTURE [J].

LIS, LJ ;

KAUFFMAN, JW ;

SHRIVER, DF .

BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 436 (03) :513-522

[9]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[10] CONFORMATION OF ADSORBED BLOOD PROTEINS BY INFRARED BOUND FRACTION MEASUREMENTS [J].

MORRISSEY, BW ;

STROMBERG, RR .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1974, 46 (01) :152-164