UBIQUITIN GENE-EXPRESSION IN SKELETAL-MUSCLE IS INCREASED BY TUMOR-NECROSIS-FACTOR-ALPHA

被引：79

作者：

GARCIAMARTINEZ, C ^{[1
]}

LLOVERA, M ^{[1
]}

AGELL, N ^{[1
]}

LOPEZSORIANO, FJ ^{[1
]}

ARGILES, JM ^{[1
]}

机构：

[1] UNIV BARCELONA, FAC BIOL, DEPT BIOQUIM & FISIOL, BARCELONA, SPAIN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 201卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.1754

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An acute intravenous administration of 100 mu g/kg body weight of recombinant tumour necrosis factor-alpha resulted in a time-dependent increase in the levels of ubiquitin mRNAs in rat skeletal muscle. The results presented here, together with previous observations demonstrating that the cytokine increases the conjugation of proteins with ubiquitin in rat skeletal muscle (1), suggest that the ubiquitin system for non-lysosomal protein degradation could have a very important role in the mechanism triggered by tumour necrosis factor-alpha which is responsible for enhanced muscle proteolysis in sepsis and other pathological states. (C) 1994 Academic Press, Inc.

引用

页码：682 / 686

页数：5

共 36 条

[1] CHARACTERIZATION OF RECEPTORS FOR HUMAN-TUMOR NECROSIS FACTOR AND THEIR REGULATION BY GAMMA-INTERFERON [J].

AGGARWAL, BB ;

EESSALU, TE ;

HASS, PE .

NATURE, 1985, 318 (6047) :665-667

[2] THE ROLE OF CYTOKINES IN MUSCLE WASTING - ITS RELATION WITH CANCER CACHEXIA [J].

ARGILES, JM ;

GARCIAMARTINEZ, C ;

LLOVERA, M ;

LOPEZSORIANO, FJ .

MEDICINAL RESEARCH REVIEWS, 1992, 12 (06) :637-652

[3] COMPARATIVE EFFECTS OF TUMOR NECROSIS FACTOR-ALPHA (CACHECTIN), INTERLEUKIN-1-BETA AND TUMOR-GROWTH ON AMINO-ACID METABOLISM IN THE RAT INVIVO - ABSORPTION AND TISSUE UPTAKE OF ALPHA-AMINO[1-C-14]ISOBUTYRATE [J].

ARGILES, JM ;

LOPEZSORIANO, FJ ;

WIGGINS, D ;

WILLIAMSON, DH .

BIOCHEMICAL JOURNAL, 1989, 261 (02) :357-362

[4]

BOND U, 1988, J BIOL CHEM, V263, P2384

[5]

BOND U, 1986, MOL CELL BIOL, V5, P584

[6]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[7] UBIQUITIN DEPENDENCE OF SELECTIVE PROTEIN-DEGRADATION DEMONSTRATED IN THE MAMMALIAN-CELL CYCLE MUTANT TS85 [J].

CIECHANOVER, A ;

FINLEY, D ;

VARSHAVSKY, A .

CELL, 1984, 37 (01) :57-66

[8] THE UBIQUITIN-MEDIATED PROTEOLYTIC PATHWAY AND MECHANISMS OF ENERGY-DEPENDENT INTRACELLULAR PROTEIN-DEGRADATION [J].

CIECHANOVER, A ;

FINLEY, D ;

VARSHAVSKY, A .

JOURNAL OF CELLULAR BIOCHEMISTRY, 1984, 24 (01) :27-53

[9] METABOLIC EFFECTS OF TUMOR NECROSIS FACTOR-ALPHA (CACHECTIN) AND INTERLEUKIN-1 [J].

EVANS, RD ;

ARGILES, JM ;

WILLIAMSON, DH .

CLINICAL SCIENCE, 1989, 77 (04) :357-364

[10] TUMOR NECROSIS FACTOR-ALPHA (CACHECTIN) MIMICS SOME OF THE EFFECTS OF TUMOR-GROWTH ON THE DISPOSAL OF A [C-14] LIPID LOAD IN VIRGIN, LACTATING AND LITTER-REMOVED RATS [J].

EVANS, RD ;

WILLIAMSON, DH .

BIOCHEMICAL JOURNAL, 1988, 256 (03) :1055-1058

← 1 2 3 4 →