A ROLE FOR A PRE-T-CELL RECEPTOR IN T-CELL DEVELOPMENT

被引：110

作者：

GROETTRUP, M

VONBOEHMER, H

机构：

[1] Basel Institute for Immunology, 4005 Basel

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 12期

关键词：

D O I：

10.1016/0167-5699(93)90201-U

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Expression of a productive T-cell receptor (TCR) beta gene has profound consequences for T-cell development, preceding an increase in thymocyte number, appearance of CD4 and CD8 coreceptors and suppression of further TCRbeta-gene rearrangement. Here Marcus Groettrup and Harald von Boehmer discuss the data obtained in various experimental models and describe a novel signal transducing receptor complex on pre-T cells, which may regulate the TCRbeta-induced developmental changes.

引用

页码：610 / 614

页数：5

共 46 条

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