HYPOGLYCEMIC EFFECT OF MOMORDICA-CHARANTIA EXTRACTS IN NORMOGLYCEMIC OR CYPROHEPTADINE-INDUCED HYPERGLYCEMIC MICE

被引：36

作者：

CAKICI, I ^{[1
]}

HURMOGLU, C ^{[1
]}

TUNCTAN, B ^{[1
]}

ABACIOGLU, N ^{[1
]}

KANZIK, I ^{[1
]}

SENER, B ^{[1
]}

机构：

[1] GAZI UNIV,DEPT PHARMACOGNOSY,ANKARA,TURKEY

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1994年 / 44卷 / 02期

关键词：

HYPOGLYCEMIC ACTIVITY; CYPROHEPTADINE; MOMORDICA CHARANTIA; MICE;

D O I：

10.1016/0378-8741(94)90077-9

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The hypoglycaemic effect of orally administered extracts of Momordica charantia L. fruits was examined in normoglycaemic or cyproheptadine-induced hyperglycaemic mice. The aqueous extract reduced the fasting glucose levels of hyperglycaemic or normoglycaemic mice. However, the ethanol extract did not affect the fasting or nonfasting glucose levels significantly in both groups of mice. There was no significant difference between the glucose-loaded and glucose-loaded plus aqueous extract given group. On the other hand, oral glucose-loading of the cyproheptadine-induced hyperglycaemic animals reduced the fasting glucose levels significantly. These results showed that aqueous extract of M. charantia fruits has a hypoglycaemic activity without improving the tolerance to glucose in cyproheptadine-induced diabetic mice.

引用

页码：117 / 121

页数：5

共 12 条

[1] HYPOGLYCEMIC EFFECT OF MOMORDICA-CHARANTIA EXTRACTS [J].