PHARMACOLOGICAL CHARACTERIZATION OF GROOMING INDUCED BY A SELECTIVE NK-1 TACHYKININ RECEPTOR AGONIST

被引：12

作者：

STOESSL, AJ

BRACKSTONE, M

RAJAKUMAR, N

GIBSON, CJ

机构：

[1] ROBARTS RES INST,LONDON,ON N6A 5C1,CANADA

[2] UNIV WESTERN ONTARIO,DEPT PATHOL,LONDON,ON,CANADA

来源：

BRAIN RESEARCH | 1995年 / 700卷 / 1-2期

关键词：

DOPAMINE; D-1; RECEPTOR; GROOMING; SUBSTANTIA NIGRA; TACHYKININ;

D O I：

10.1016/0006-8993(95)00940-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bilateral intranigral administration of the selective NK-1 tachykinin receptor agonist [AcArg(6),Sar(9),Met(O-2)(11)]SP6-11 (0-1 nmol total bilateral dose) selectively induced grooming in rats. This response was blocked by concurrent intranigral administration of the NK-1 tachykinin receptor antagonist RP 67580 (2 nmol), but not by NK-2 (L-659,877) or NK-3 ([Trp(7), beta-Ala(8)]NKA(4-10)) antagonists. Pretreatment with systemic opioid (naloxone 1.5 mg/kg) and D-1 dopamine (SCH 23390 100 mu g/kg) receptor antagonists also attenuated tachykinin-induced grooming, which was unaffected by D-2 dopamine (sulpiride 30 mg/kg) or 5-HT2A+C (ritanserin 2 mg/kg) antagonists. Grooming induced by intranigral [AcArg(6),Sar(9),Met(O-2)(11)]SP6-11 was also attenuated by bilateral 6-hydroxydopamine lesions of the substantia nigra. These findings indicate that grooming induced by intranigral tachykinins reflects activation of NK-1 receptors and is dependent upon endogenous dopamine and consequent selective stimulation of D-1 dopamine receptors.

引用

页码：115 / 120

页数：6

共 37 条

[1]

Bannon, Elliott, Bunney, Striatal tachykinin biosynthesis: regulation of mRNA and peptide levels by dopamine agonists and antagonists, Mol. Brain Res., 3, pp. 31-37, (1987)

[2]

Baruch, Artaud, Godeheu, Barbeito, Glowinski, Cheramy, Substance P and neurokinin A regulate by different mechanisms dopamine release from dendrites and nerve terminals of the nigrostriatal dopaminergic neurons, Neuroscience, 25, pp. 889-898, (1988)

[3]

Besson, Graybiel, Nastuk, [3H]SCH 23390 binding to D1 dopamine receptors in the basal ganglia of the cat and primate: delineation of striosomal compartments and pallidal and nigral subdivisions, Neuroscience, 26, pp. 101-119, (1988)

[4]

Bischoff, Heinrich, Sonntag, Krauss, The D1 dopamine receptor antagonist SCH 23390 also interacts potently with brain serotonin (5-HT2) receptors, Eur. J. Pharmacol., 129, pp. 367-370, (1986)

[5]

Dam, Escher, Quirion, Visualization of neurokinin-3 receptor sites in rat brain using the highly selective ligand [3H]senktide, Brain Res., 506, pp. 175-179, (1990)

[6]

Davies, Dray, Substance P in the substantia nigra, Brain Res., 107, pp. 623-627, (1976)

[7]

Drapeau, Rouissi, Nantel, Rhaleb, Tousignant, Regoli, Antagonists for the neurokinin NK-3 receptor evaluated in selective receptor systems, Regul. Peptides, 31, pp. 125-135, (1990)

[8]

Eison, Eison, Iversen, The behavioural effects of a novel substance P analogue following infusion into the ventral tegmental area of substantia nigra of rat brain, Brain Res., 238, pp. 137-152, (1982)

[9]

Elliott, Iversen, Behavioural effects of tachykinins and related peptides, Brain Res., 381, pp. 68-76, (1986)

[10]

Emson, Arregui, Clement-Jones, Sandberg, Rossor, Regional distribution of methionine enkephalin and substance P-like immunoreactivity in normal human brain in Huntington's disease, Brain Res., 199, pp. 147-160, (1980)

← 1 2 3 4 →