NITRIC-OXIDE INHIBITS DEPOLARIZATION-INDUCED RELEASE OF ENDOGENOUS DOPAMINE IN THE RABBIT RETINA

被引：39

作者：

DJAMGOZ, MBA ^{[1
]}

CUNNINGHAM, JR ^{[1
]}

DAVENPORT, SL ^{[1
]}

NEAL, MJ ^{[1
]}

机构：

[1] UNITED MED & DENT SCH,ST THOMAS HOSP,DEPT PHARMACOL,LONDON SE1 7EH,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1995年 / 198卷 / 01期

关键词：

NITRIC OXIDE; DOPAMINE; GABA; BICUCULLINE; RETINA; LIGHT ADAPTATION; AMACRINE CELL; RABBIT;

D O I：

10.1016/0304-3940(95)11958-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of nitric oxide donor compounds (sodium nitroprusside, hydroxylamine and S-nitroso-N-acetyl-D,L-penicillamine) on depolarization-induced release of endogenous dopamine in the light-adapted, isolated retina of the rabbit was studied by HPLC. All three compounds had the same effect, reducing the amount of dopamine released by up to 90%. The effect was concentration dependent, saturating at 300 mu M; it was blocked by the nitric oxide scavenger, mannitol (50 mM), which by itself had no effect on the basal release of dopamine. GABA(A) receptors were not involved. Possible cellular mechanisms underlying the findings are discussed. It is suggested that the inhibitory interaction between dopamine and nitric oxide could represent a higher order function in the light adaptation process in the retina.

引用

页码：33 / 36

页数：4

共 23 条

[1]

[Anonymous], 1987, RETINA APPROACHABLE

[2] BACKGROUND ILLUMINATION REDUCES HORIZONTAL CELL RECEPTIVE-FIELD SIZE IN BOTH NORMAL AND 6-HYDROXYDOPAMINE-LESIONED GOLDFISH RETINAS [J].

BALDRIDGE, WH ;

BALL, AK .

VISUAL NEUROSCIENCE, 1991, 7 (05) :441-450

[3] THE ON-BIPOLAR AGONIST, L-2-AMINO-4-PHOSPHONOBUTYRATE, BLOCKS LIGHT-EVOKED CONE CONTRACTION IN XENOPUS EYE CUPS [J].

BESHARSE, JC .

NEUROCHEMICAL RESEARCH, 1992, 17 (01) :75-80

[4]

BOLTINA VM, 1994, NATURE, V368, P850

[5] NITRIC-OXIDE MODULATES ENDOGENOUS DOPAMINE RELEASE IN BOVINE RETINA [J].

BUGNON, O ;

SCHAAD, NC ;

SCHORDERET, M .

NEUROREPORT, 1994, 5 (04) :401-404

[6] LOCALIZATION AND FUNCTION OF DOPAMINE IN THE ADULT VERTEBRATE RETINA [J].

DJAMGOZ, MBA ;

WAGNER, HJ .

NEUROCHEMISTRY INTERNATIONAL, 1992, 20 (02) :139-191

[7]

DJAMGOZ MBA, IN PRESS NEUROCHEM I

[8] THE RELATIONSHIP BETWEEN LIGHT, DOPAMINE RELEASE AND HORIZONTAL CELL COUPLING IN THE MUDPUPPY RETINA [J].

DONG, CJ ;

MCREYNOLDS, JS .

JOURNAL OF PHYSIOLOGY-LONDON, 1991, 440 :291-309

[9] THE EFFECT OF DOPAMINE DEPLETION ON LIGHT-EVOKED AND CIRCADIAN RETINOMOTOR MOVEMENTS IN THE TELEOST RETINA [J].

DOUGLAS, RH ;

WAGNER, HJ ;

ZAUNREITER, M ;

BEHRENS, UD ;

DJAMGOZ, MBA .

VISUAL NEUROSCIENCE, 1992, 9 (3-4) :335-343

[10] NITRIC-OXIDE INDUCES LIGHT-ADAPTIVE MORPHOLOGICAL-CHANGES IN RETINAL NEURONS [J].

GREENSTREET, EH ;

DJAMGOZ, MBA .

NEUROREPORT, 1994, 6 (01) :109-112

← 1 2 3 →