CONVERTING ENZYME-INHIBITORS REGRESSED CARDIAC-HYPERTROPHY AND REDUCED TISSUE ANGIOTENSIN-II IN SPONTANEOUSLY HYPERTENSIVE RATS

被引：126

作者：

NAGANO, M ^{[1
]}

HIGAKI, J ^{[1
]}

MIKAMI, H ^{[1
]}

NAKAMARU, M ^{[1
]}

HIGASHIMORI, K ^{[1
]}

KATAHIRA, K ^{[1
]}

TABUCHI, Y ^{[1
]}

MORIGUCHI, A ^{[1
]}

NAKAMURA, F ^{[1
]}

OGIHARA, T ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT GERIATR MED,FUKUSHIMA KU,OSAKA 553,JAPAN

来源：

JOURNAL OF HYPERTENSION | 1991年 / 9卷 / 07期

关键词：

ANGIOTENSIN-II; CONVERTING ENZYME INHIBITOR; ENALAPRIL; LEFT VENTRICULAR HYPERTROPHY; SPONTANEOUSLY HYPERTENSIVE RAT; TRANDOLAPRIL;

D O I：

10.1097/00004872-199107000-00003

中图分类号：

R6 [外科学];

学科分类号：

1002 [临床医学]; 100210 [外科学];

摘要：

To examine the role of the tissue renin-angiotensin system in left ventricular hypertrophy, converting enzyme inhibitors were administered orally to 12-week-old male spontaneously hypertensive rats (SHR) for 4 weeks, and cardiac tissue angiotensin II was measured. Treatment with enalapril (10 mg/kg per day) and trandolapril (1 mg/kg per day) lowered systolic blood pressure, left ventricular weight and left ventricular angiotensin II content. Plasma angiotensin II concentration was increased by the treatment with enalapril whereas trandolapril did not cause any change. There was significantly positive correlation between left ventricular weight and angiotensin II content. Because angiotensin II promotes cell proliferation, these results suggest that cardiac tissue angiotensin II, rather than circulating angiotensin II, may account for the pathophysiology of left ventricular hypertrophy in SHR.

引用

页码：595 / 599

页数：5

共 20 条

[1]

SERIAL RENIN-ANGIOTENSIN STUDIES IN SPONTANEOUSLY HYPERTENSIVE AND WISTAR-KYOTO NORMOTENSIVE RATS - TRANSITION FROM NORMAL-RENIN TO HIGH-RENIN STATUS DURING THE ESTABLISHED PHASE OF SPONTANEOUS HYPERTENSION [J].