HEPATIC-METABOLISM OF ARTEMISININ DRUGS .3. INDUCTION OF HYDROGEN-PEROXIDE PRODUCTION IN RAT-LIVER MICROSOMES BY ARTEMISININ DRUGS

被引：7

作者：

LESKOVAC, V ^{[1
]}

PEGGINS, JO ^{[1
]}

机构：

[1] WALTER REED ARMY MED CTR, DIV EXPTL THERAPEUT, WASHINGTON, DC 20307 USA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | 1992年 / 101卷 / 02期

关键词：

D O I：

10.1016/0742-8413(92)90261-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. In this communication, induction of hydrogen peroxide production by the semisynthetic antimalarial drugs of the artemisinin class (beta-arteether, beta-artelinic acid and dihydroartemisinin) in rat liver microsomes, is reported. 2. Endogenous, NADPH-dependent, production of hydrogen peroxide in rat liver microsomes was enhanced in the presence of arteether and artelinic acid, but not in the presence of dihydroartemisinin. 3. NADPH-dependent metabolism of arteether and artelinic acid was closely coupled to the drug-induced production of hydrogen peroxide. 4. The redox cycle of cytochrome P-450 was presented, which describes satisfactorily both the endogenous and the drug-assisted hydrogen peroxide production in rat liver microsomes; also, the rate-limiting step of the cycle was identified.

引用

页码：203 / 208

页数：6

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