PROTON NMR-SPECTROSCOPY OF CANAVANS DISEASE

被引：42

作者：

BARKER, PB

BRYAN, RN

KUMAR, AJ

NAIDU, S

机构：

[1] JOHNS HOPKINS UNIV HOSP,DEPT NEUROL,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV HOSP,DEPT RADIOL,BALTIMORE,MD 21205

来源：

NEUROPEDIATRICS | 1992年 / 23卷 / 05期

关键词：

N-ACETYL-ASPARTATE; NMR SPECTROSCOPY; CANAVANS DISEASE;

D O I：

10.1055/s-2008-1071355

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Proton Nuclear Magnetic Resonance (NMR) spectroscopy was used to quantitatively determine cerebral N-Acetyl Aspartate (NAA) concentrations in four patients with Canavan's disease and in four age-matched control subjects. Macroscopic NAA concentrations (mumol/gm wet weight) were not found to be significantly different from controls. Reduced levels of choline and creatine were observed in all patients, and increased levels of lactate and inositol in the eldest three patients.

引用

页码：263 / 267

页数：5

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