GALLIUM NITRATE - A REVIEW OF ITS PHARMACOLOGICAL PROPERTIES AND THERAPEUTIC POTENTIAL IN CANCER-RELATED HYPERCALCEMIA

被引：45

作者：

TODD, PA ^{[1
]}

FITTON, A ^{[1
]}

机构：

[1] ADIS INT LTD, 41 CENTORIAN DR, MAIRANGI BAY, AUCKLAND 10, NEW ZEALAND

来源：

DRUGS | 1991年 / 42卷 / 02期

关键词：

D O I：

10.2165/00003495-199142020-00007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Gallium nitrate, a novel drug for the treatment of cancer-related hypercalcaemia, inhibits osteoclast activity but does not affect osteoclast morphology or viability. Limited clinical experience in patients with cancer-related hypercalcaemia indicates that gallium nitrate is effective in restoring normocalcaemia in 75 to 85% of patients and is well tolerated in those with preserved renal function, producing few clinically relevant adverse effects. In comparative clinical trials it proved a more effective antihypercalcaemic agent than calcitonin or etidronate and produced a longer lasting normocalcaemic response. Gallium nitrate would appear to be indicated in symptomatic patients with cancer-related hypercalcaemia who have failed to respond to adequate rehydration.

引用

页码：261 / 273

页数：13

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