DETERIORATION ON THE BLESSED TEST IN ALZHEIMERS-DISEASE - LONGITUDINAL DATA AND THEIR IMPLICATIONS FOR CLINICAL-TRIALS AND IDENTIFICATION OF SUBTYPES

被引:44
作者
STERN, RG
MOHS, RC
BIERER, LM
SILVERMAN, JM
SCHMEIDLER, J
DAVIDSON, M
DAVIS, KL
机构
[1] VET ADM MED CTR,PSYCHIAT SERV,BRONX,NY 10468
[2] VET ADM MED CTR,BIOMATH SCI,BRONX,NY 10468
关键词
DEMENTIA; MEMORY; GERIATRIC PSYCHIATRY;
D O I
10.1016/0165-1781(92)90074-D
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
One hundred eleven patients with probable Alzheimer's disease (AD) were given the Blessed test (BT) of information, memory, and concentration (scored 0-33) at 6-month intervals over periods of 6-96 months. For each patient, the change in the total BT score between pairs of visits at 6- and 12-month intervals was measured. Mean deterioration scores over 6 and 12 months were 2.2 (SD = 3.2) and 4.1 (SD = 4.1) points, respectively. There was no significant correlation between degree of dementia on the BT and the rate of deterioration. Gender, age of onset, and family history had no significant effect on the rate of deterioration. The implications of the results for treatment trials and investigations of clinical heterogeneity are discussed.
引用
收藏
页码:101 / 110
页数:10
相关论文
共 22 条
[1]   ASSOCIATION BETWEEN QUANTITATIVE MEASURES OF DEMENTIA AND OF SENILE CHANGE IN CEREBRAL GREY MATTER OF ELDERLY SUBJECTS [J].
BLESSED, G ;
TOMLINSON, BE ;
ROTH, M .
BRITISH JOURNAL OF PSYCHIATRY, 1968, 114 (512) :797-+
[2]  
BRANDT J, 1989, NEUROPSY NEUROPSY BE, V2, P93
[3]   PROGRESSION OF COGNITIVE IMPAIRMENT IN ALZHEIMERS-DISEASE [J].
BURNS, A ;
JACOBY, R ;
LEVY, R .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1991, 39 (01) :39-45
[4]   CLINICAL SUBTYPES OF DEMENTIA OF THE ALZHEIMER TYPE [J].
CHUI, HC ;
TENG, EL ;
HENDERSON, VW ;
MOY, AC .
NEUROLOGY, 1985, 35 (11) :1544-1550
[5]   NEUROPSYCHOLOGICAL FEATURES OF EARLY-ONSET AND LATE-ONSET ALZHEIMERS-DISEASE [J].
FILLEY, CM ;
KELLY, J ;
HEATON, RK .
ARCHIVES OF NEUROLOGY, 1986, 43 (06) :574-576
[6]   MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].
FOLSTEIN, MF ;
FOLSTEIN, SE ;
MCHUGH, PR .
JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198
[7]  
HESTON LL, 1986, CAN J NEUROL SCI, V13, P432
[8]   AGE AT ONSET AND RATE OF PROGRESSION OF ALZHEIMERS-DISEASE [J].
HUFF, FJ ;
GROWDON, JH ;
CORKIN, S ;
ROSEN, TJ .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1987, 35 (01) :27-30
[9]   COMPARISON OF RATE OF ANNUAL CHANGE OF MENTAL STATUS SCORE IN 4 INDEPENDENT STUDIES OF PATIENTS WITH ALZHEIMERS-DISEASE [J].
KATZMAN, R ;
BROWN, T ;
THAL, LJ ;
FULD, PA ;
ARONSON, M ;
BUTTERS, N ;
KLAUBER, MR ;
WIEDERHOLT, W ;
PAY, M ;
RENBING, X ;
OOI, WL ;
HOFSTETTER, R ;
TERRY, RD .
ANNALS OF NEUROLOGY, 1988, 24 (03) :384-389
[10]  
KRAMERGINSBERG E, 1988, PSYCHOPHARMACOL BULL, V24, P458