INHIBITION OF ISLET NITRIC-OXIDE SYNTHASE INCREASES ARGININE-INDUCED INSULIN RELEASE

被引：56

作者：

PANAGIOTIDIS, G ^{[1
]}

ALM, P ^{[1
]}

LUNDQUIST, I ^{[1
]}

机构：

[1] UNIV LUND,DEPT PATHOL,S-22101 LUND,SWEDEN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 229卷 / 2-3期

关键词：

INSULIN RELEASE; NO SYNTHASE INHIBITION; ARGININE; NADPH DIAPHORASE;

D O I：

10.1016/0014-2999(92)90568-O

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

N(G)-Nitro-L-arginine, an inhibitor of nitric oxide (NO) synthase, markedly (+50%) increased the L-arginine-induced insulin release from isolated mouse islets but did not itself influence insulin secretion. An abundance of mouse islet cells were positively stained for the enzyme NADPH diaphorase, which reportedly is a marker for NO synthase. The data suggest that the NO synthase activity in mouse islet tissue may inhibit insulin secreting processes and that L-arginine has a dual action on insulin release.

引用

页码：277 / 278

页数：2

共 5 条

[1]

ALM P, IN PRESS ACTA PHYSL

[2] DOES NITRIC-OXIDE MEDIATE AUTOIMMUNE DESTRUCTION OF BETA-CELLS - POSSIBLE THERAPEUTIC INTERVENTIONS IN IDDM [J].