STRUCTURAL STUDY OF DEHYDROCURVULARIN, AN INHIBITOR OF MICROTUBULE ASSEMBLY

被引：17

作者：

ALMASSI, F

GHISALBERTI, EL

SKELTON, BW

WHITE, AH

机构：

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 1994年 / 47卷 / 06期

关键词：

D O I：

10.1071/CH9941193

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

The solid-state structure of the fungal metabolite E-dehydrocurvularin (2), an inhibitor of microtubule assembly, has been determined by a single-crystal room-temperature X-ray study for comparison with curvularin (1). Crystals of (2) are orthorhombic, P2(1)2(1)2(1), a 17 . 757(9), b 10.031(6), c 8.069(4) angstrom, z = 4, R was 0.060 for 988 independent 'observed' [I > 3sigma(I)] diffractometer reflections. The results of this study show that (1) and (2) adopt opposite helicity in the solid state.

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页码：1193 / 1197

页数：5

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