POTENTIATION OF METASTATIC CAPACITY BY TRANSFORMING GROWTH-FACTOR-BETA-1 GENE TRANSFECTION

被引：26

作者：

UEKI, N ^{[1
]}

OHKAWA, T ^{[1
]}

YOKOYAMA, Y ^{[1
]}

MAEDA, J ^{[1
]}

KAWAI, Y ^{[1
]}

IKEDA, T ^{[1
]}

AMURO, Y ^{[1
]}

HADA, T ^{[1
]}

HIGASHINO, K ^{[1
]}

机构：

[1] MORINAGA INST BIOL SCI,TSURUMI KU,YOKOHAMA,KANAGAWA 230,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1993年 / 84卷 / 06期

关键词：

TRANSFORMING GROWTH FACTOR-BETA-1; GENE TRANSFER; ANGIOGENESIS; LUNG METASTASIS;

D O I：

10.1111/j.1349-7006.1993.tb02017.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study was designed to assess whether the excessive secretion of transforming growth factor-beta1 (TGF-beta1) by Chinese hamster ovary (CHO) cells transfected with TGF-beta1 gene may be linked to the development of a metastatic phenotype. We observed large numbers of metastatic colonies in the lungs of nude mice inoculated with the transfected CHO cells. The tumors derived from these transfected celts demonstrated marked angiogenesis. We postulate that the overproduction of TGF-beta1 by these tumors may participate in the metastatic progression following establishment of angiogenesis at the primary tumor site.

引用

页码：589 / 593

页数：5

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