CHOLINOTOXIC EFFECTS OF BETA-AMYLOID((1-42)) PEPTIDE ON CORTICAL PROJECTIONS OF THE RAT NUCLEUS BASALIS MAGNOCELLULARIS

被引：62

作者：

HARKANY, T

LENGYEL, Z

SOOS, K

PENKE, B

LUITEN, PG

GULYA, K

机构：

[1] ATTILA JOZSEF UNIV,DEPT ZOOL & CELL BIOL,H-6722 SZEGED,HUNGARY

[2] ALBERT SZENT GYORGYI MED UNIV,DEPT MED CHEM,H-6701 SZEGED,HUNGARY

[3] UNIV GRONINGEN,DEPT ANIM PHYSIOL,GRONINGEN,NETHERLANDS

来源：

BRAIN RESEARCH | 1995年 / 695卷 / 01期

关键词：

BETA-AMYLOID((1-42)) PEPTIDE; NUCLEUS BASALIS MAGNOCELLULARIS; FRONTAL CORTEX; CHOLINERGIC SYSTEM; CHOLINOTOXICITY;

D O I：

10.1016/0006-8993(95)00823-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

beta-Amyloid((1-42)) peptide (beta AP) was injected into the right nucleus basalis magnocellularis (nbm) of rats. After a 14-day survival time, the acetylcholinesterase and choline acetyltransferase activities and the number of muscarinic receptors were found biochemically to be significantly reduced in the ipsilateral frontal cortices. Confirmation of these data with silver staining also revealed degeneration of the projective fibers of the nbm to the frontal cortex. These results demonstrate the cholinotoxicity of beta AP in an in vivo animal model.

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页码：71 / 75

页数：5

相关论文

共 21 条

[1] SOLUTION STRUCTURES OF BETA PEPTIDE AND ITS CONSTITUENT FRAGMENTS - RELATION TO AMYLOID DEPOSITION [J].

BARROW, CJ ;

ZAGORSKI, MG .

SCIENCE, 1991, 253 (5016) :179-182

[2] THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION [J].

BARTUS, RT ;

DEAN, RL ;

BEER, B ;

LIPPA, AS .

SCIENCE, 1982, 217 (4558) :408-417

[3] A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY [J].

ELLMAN, GL ;

COURTNEY, KD ;

ANDRES, V ;

FEATHERSTONE, RM .

BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) :88-&

[4] RAPID RADIOCHEMICAL METHOD FOR DETERMINATION OF CHOLINE-ACETYLTRANSFERASE [J].

FONNUM, F .

JOURNAL OF NEUROCHEMISTRY, 1975, 24 (02) :407-409

[5] A RELIABLE AND SENSITIVE METHOD TO LOCALIZE TERMINAL DEGENERATION AND LYSOSOMES IN THE CENTRAL NERVOUS-SYSTEM [J].

GALLYAS, F ;

WOLFF, JR ;

BOTTCHER, H ;

ZABORSZKY, L .

STAIN TECHNOLOGY, 1980, 55 (05) :299-306

[6] LACK OF ALZHEIMER PATHOLOGY AFTER BETA-AMYLOID PROTEIN INJECTIONS IN RAT-BRAIN [J].

GAMES, D ;

KHAN, KM ;

SORIANO, FG ;

KEIM, PS ;

DAVIS, DL ;

BRYANT, K ;

LIEBERBURG, I .

NEUROBIOLOGY OF AGING, 1992, 13 (05) :569-576

[7] ALZHEIMERS-DISEASE - INITIAL REPORT OF THE PURIFICATION AND CHARACTERIZATION OF A NOVEL CEREBROVASCULAR AMYLOID PROTEIN [J].

GLENNER, GG ;

WONG, CW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (03) :885-890

[8] AMYLOID BETA-PEPTIDE IS PRODUCED BY CULTURED-CELLS DURING NORMAL METABOLISM [J].

HAASS, C ;

SCHLOSSMACHER, MG ;

HUNG, AY ;

VIGOPELFREY, C ;

MELLON, A ;

OSTASZEWSKI, BL ;

LIEBERBURG, I ;

KOO, EH ;

SCHENK, D ;

TEPLOW, DB ;

SELKOE, DJ .

NATURE, 1992, 359 (6393) :322-325

[9] THE PRECURSOR OF ALZHEIMERS-DISEASE AMYLOID-A4 PROTEIN RESEMBLES A CELL-SURFACE RECEPTOR [J].

KANG, J ;

LEMAIRE, HG ;

UNTERBECK, A ;

SALBAUM, JM ;

MASTERS, CL ;

GRZESCHIK, KH ;

MULTHAUP, G ;

BEYREUTHER, K ;

MULLERHILL, B .

NATURE, 1987, 325 (6106) :733-736

[10] THE CHOLINERGIC SYSTEMS IN BRAIN AND SPINAL-CORD [J].

KASA, P .

PROGRESS IN NEUROBIOLOGY, 1986, 26 (03) :211-+