NEAR-UV-INDUCED BREAKS IN PHAGE DNA - SENSITIZATION BY HYDROGEN-PEROXIDE (A TRYPTOPHAN PHOTOPRODUCT)

被引：71

作者：

ANANTHASWAMY, HN ^{[1
]}

EISENSTARK, A ^{[1
]}

机构：

[1] UNIV MISSOURI, DIV BIOL SCI, COLUMBIA, MO 65201 USA

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1976年 / 24卷 / 05期

关键词：

D O I：

10.1111/j.1751-1097.1976.tb06851.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Near-UV irradiation of L-tryptophan yields a large number of photoproducts. When this mixture is added to recombinationless (rec) mutants of bacteria, the cells are killed. The most toxic component of tryptophan photoproducts was identified as H2O2. In this report tryptophan photoproducts and H2O2 sensitized phage DNA [from T2, T3, T4, T5 and T7] to near-UV radiation resulting in enhanced killing and enhanced DNA breakages. The in situ production of H2O2 via tryptophan photolysis may be an important biological event.

引用

页码：439 / 442

页数：4

共 19 条

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