DIFFERENTIAL-EFFECTS OF APOMORPHINE ON PREPULSE INHIBITION OF ACOUSTIC STARTLE REFLEX IN 2 RAT STRAINS

被引：85

作者：

RIGDON, GC

机构：

[1] Pharmacology Division, Burroughs Wellcome Co., Research Triangle Park, 27709, NC

来源：

PSYCHOPHARMACOLOGY | 1990年 / 102卷 / 03期

关键词：

Apomorphine; CD strain; Prepulse inhibition; Startle reflex; Wistar strain;

D O I：

10.1007/BF02244115

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Apomorphine disruption of prepulse inhibition (PPI) has been proposed as an animal model of sensorimotor gating deficits exhibited by schizophrenics. The effects of apomorphine on PPI of the acoustic startle reflex in male rats of Wistar and CD (Sprague-Dawley derived) strains were compared under identical test conditions. In Wistar rats, subcutaneous administration of 0.25-1.0 mg/kg apomorphine blocked PPI without affecting startle amplitude. In CD rats, apomorphine (0.3-3.0 mg/kg, SC) had no effect on PPI, but increased startle amplitude. Therefore, choice of rat strain is an important factor in the design of experiments studying apomorphine effects on PPI. © 1990 Springer-Verlag.

引用

页码：419 / 421

页数：3

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