NUCLEAR RECEPTORS AND CHEMICAL CARCINOGENESIS

被引：25

作者：

GREEN, S

机构：

[1] S. Green is Molecular Biology Group Leader, Imperial Chemical Industries PLC, Central Toxicology Laboratory, Macclesfield, Cheshire SK10 4TJ, Alderley Park

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1992年 / 13卷 / 06期

关键词：

D O I：

10.1016/0165-6147(92)90078-K

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A number of non-genotoxic chemical carcinogens can recognize specific intracellular proteins. These cellular targets include members of the nuclear receptor family of ligand-activated transcription factors. Some non-genotoxic carcinogens appear to mimic the action of hormones and growth factors and perturb signal transduction pathways. Their carcinogenic activity may therefore result from the persistent stimulation of such pathways, promoting the growth of initiated cells.

引用

页码：251 / 255

页数：5

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