GASTROINTESTINAL TRANSIT OF NONDISINTEGRATING, NONERODIBLE ORAL DOSAGE FORMS IN PIGS

Gastrointestinal (GI) transit data necessary as “baseline” or “control” information were collected using pigs as animal models preliminary to bioavailability studies of new sustained action formulations. Density and size effects of nondisintegrating dosage forms on GI transit were investigated. Initially, enteric-coated nondisintegrating magnesium hydroxide caplets (density, 1.5 g/ml; size, 19.6 × 9.5 mm; weight, 1.2 g) were utilized in seven pigs. Prolonged gastric residence (>5 days) occurred in every case for this dosage form. Therefore, nondisintegrating caplets of three densities (1.25, 1.45, and 2.3 g/ml) and three different sizes (large, 20 × 10 mm; medium, 10 × 10 mm; small, 5 × 10 mm) were studied in two more pigs. Roentgenography was used to visualize passage of caplets through the GI tract. Heidelberg pH capsules (size, 8 × 20 mm; density, 1.61 g/ml) were also used in this study. Total GI transit times range from 2 to 33 days for 22 administrations of these nondisintegrating dosage forms. Pigs are found to not be an appropriate model for evaluating bioavailability of nondisintegrating controlled-release dosage forms because total GI transit time (especially gastric transit) is much too long. © 1990, Plenum Publishing Corporation. All rights reserved.