POSSIBLE AGONISTIC INTERACTION OF DEFIBROTIDE, A DNA DERIVATIVE, WITH ADENOSINE RECEPTORS INVITRO

被引：3

作者：

BIANCHI, G ^{[1
]}

MANTOVANI, M ^{[1
]}

PRINO, G ^{[1
]}

SALVETTI, L ^{[1
]}

BARONE, D ^{[1
]}

机构：

[1] IST RIC BIOMED RBM,I-10010 COLLERETTO G,ITALY

来源：

NUCLEOSIDES & NUCLEOTIDES | 1991年 / 10卷 / 05期

关键词：

D O I：

10.1080/07328319108047258

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Defibrotide (DFT), a single-stranded DNA, dose-dependently displaced only 3H-CHA and 3H-NECA (markers of adenosine receptors), among 37 radioligands tested. On isolated gastro-intestinal smooth muscle, DFT caused a dose-dependent relaxation, that was antagonized by 8-phenyltheophylline, a mixed A1- and A2-receptor antagonist.

引用

页码：1149 / 1150

页数：2