INTERLEUKIN-6 PRODUCTION BY THYROID EPITHELIAL-CELLS - ENHANCEMENT BY INTERLEUKIN-1

被引：35

作者：

DIAMANT, M

KAYSER, L

RASMUSSEN, AK

BECH, K

FELDTRASSMUSSEN, U

机构：

[1] Laboratory of Medical Immunology, Rigshospitalet

[2] Institute of Medical Anatomy, Dept. A, The Panum Institute

[3] Medical Dept. of Endocrinology, Frederiksberg Hospital

[4] Medical Dept. P, Rigshospitalet, Copenhagen

来源：

AUTOIMMUNITY | 1991年 / 11卷 / 01期

关键词：

CYTOKINES; INTERLEUKIN-6; INTERLEUKIN-1; HUMAN THYROID CELLS; RAT THYROID CELL LINE;

D O I：

10.3109/08916939108994704

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-1 is a potent inhibitor of thyroglobulin and cAMP production in human thyroid cells and the inhibitory effect is enhanced by tumor necrosis factor-α and interferon-β In the present study secondary cultures of human thyroid cells produced interleukin-6 and the production was significantly increased after exposure of the cells to recombinant interleukin-α and -1β This increase was dose-dependent and concomitant of the IL-1 induced decrease in cAMP and thyroglobulin production. Both tumor necrosis factor-α and -β also augmented interleukin-6 production, but less potently than interleukin-1. Interferon-γ did not affect the production of interleukin-6. The rat thyroid cell line FRTL-5 produced interleukin-6 spontaneously, and the production was enhanced after addition of recombinant interleukin-1β. A pathogenetic role of interleukin-6 in autoimmune thyroid disease is suggested. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：21 / 26

页数：6

共 26 条

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