ALTERED LEVELS OF URINARY PROSTANOIDS IN LEAD-EXPOSED WORKERS

被引：14

作者：

HOTTER, G ^{[1
]}

FELS, LM ^{[1
]}

CLOSA, D ^{[1
]}

ROSELLO, J ^{[1
]}

STOLTE, H ^{[1
]}

GELPI, E ^{[1
]}

机构：

[1] HANNOVER MED SCH,DEPT NEPHROL,W-3000 HANNOVER,GERMANY

来源：

TOXICOLOGY LETTERS | 1995年 / 77卷 / 1-3期

关键词：

LEAD; KIDNEY; PROSTANOIDS;

D O I：

10.1016/0378-4274(95)03311-4

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 [卫生毒理学];

摘要：

This paper describes the alteration of the urinary excretion of prostanoids in workers occupationally exposed to lead. For this purpose, the following groups were studied: Group 1 (n = 62): controls; Group 2 (n = 29): risk group; and Group 3 (n = 69): exposed group. Urine samples were collected for prostanoid analysis and lead blood levels were analyzed. Our results demonstrate that urinary excretion of prostanoids is already altered even at levels of lead in blood = 200 mu g/l. Owing to their sensitivity, urinary prostanoids could be useful markers of early renal changes associated with lead exposure. However, underlying mechanisms should be elucidated and the health significance of such changes should be assessed before any conclusion is drawn.

引用

页码：309 / 312

页数：4

共 13 条

[1]

MODERN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC-RADIOIMMUNOASSAY STRATEGIES FOR THE STUDY OF EICOSANOIDS IN BIOLOGICAL SAMPLES [J].