SYNTHESIS OF SUBSTITUTED 5-AMINO-8-PHENYL-3H,6H-1,4,5A,8A-TETRAAZAACENAPHTHALEN-3-ONES, A NEW CLASS OF AGENTS FOR THE IMPROVEMENT OF COGNITION

被引：10

作者：

LEVIN, JI

EPSTEIN, JW

BEER, B

DEAN, WD

DUSZA, JP

TSENG, SS

SCHWEITZER, HJ

FRANCISCO, GD

CAIN, WT

BARTUS, RT

DEAN, RL

机构：

[1] American Cyanamid Company Medical Research Division, Lederle Laboratories Pearl River

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(01)81101-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of the novel 5-amino-8-phenyl-3H,6H-1,4,5a,8a-tetraazaacenaphthalen-3-one ring system has yielded several compounds which display activity in the reversal of cognition deficits in rats and mice as compared to existing reference agents. Activity was determined by improvements in Hypoxic Survival and Anoxic-Induced Amnesia tests.

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页码：435 / 440

页数：6

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