QUANTIFICATION OF PLAQUE TYPES IN SULCI AND GYRI OF THE MEDIAL FRONTAL-LOBE IN PATIENTS WITH ALZHEIMERS-DISEASE

被引：20

作者：

MCKENZIE, JE

GENTLEMAN, SM

ROYSTON, MC

EDWARDS, RJ

ROBERTS, GW

机构：

[1] CHARING CROSS & WESTMINSTER MED SCH,DEPT PSYCHIAT,LONDON,ENGLAND

[2] CHARING CROSS & WESTMINSTER MED SCH,DEPT ANT,LONDON,ENGLAND

[3] ST MARYS HOSP,SCH MED,IMPERIAL COLL,DEPT ANAT,NORFOLK PL,LONDON W2 1PG,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1992年 / 143卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

BETA-A4; AMYLOID; CLASSIC PLAQUE; DIFFUSE PLAQUE; IMAGE ANALYSIS; SULCUS; GYRUS; ALZHEIMERS DISEASE;

D O I：

10.1016/0304-3940(92)90224-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Beta-Amyloid protein (beta-A4) deposition was characterised in the sulci and gyri of frontal cortex in 14 cases of Alzheimer's disease. A quantitative study was made of two distinct plaque sub-types (diffuse and classic) using immunocytochemistry and image analysis using a discriminant function design. As reported previously more beta-A4 was observed in sulci than gyri. Diffuse plaques were more numerous than classic plaques in sulci and gyri (P<0.01). Classic plaques were more abundant in the sulci (P<0.01). Increased beta-A4 deposition in the sulci is accounted for by increased numbers of classic plaques. No correlation was observed between the numbers of diffuse and classic plaques in either region. Our data suggest that the two plaque types form discrete populations and that their evolution is governed by distinct pathophysiological parameters.

引用

页码：23 / 26

页数：4

共 24 条

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