THE 3-BETA-HYDROXYSTEROID DEHYDROGENASE GENE FAMILY OF ENZYMES

被引：80

作者：

MASON, JI ^{[1
]}

机构：

[1] UNIV TEXAS, SW MED CTR, DEPT OBSTET & GYNECOL, DALLAS, TX 75235 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1993年 / 4卷 / 06期

关键词：

D O I：

10.1016/1043-2760(93)90117-W

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It now is apparent that a family of closely related genes encode for 3beta-hydroxysteroid dehydrogenase (3betaHSD). Studies on the regulation of these genes are in their infancy, but the regulation appears multifactorial. The various 3betaHSD genes are expressed principally in a tissue-specific manner likely involving separate mechanisms of regulation. To date, two human 3betaHSD genes and their products have been characterized; type I is expressed in placenta, sebaceous glands, and several other nonendocrine tissues, whereas the type II isoform is the principal 3betaHSD of adrenal cortex and gonads.

引用

页码：199 / 203

页数：5

共 38 条

[1] MULTIPLE FORMS OF MOUSE 3-BETA-HYDROXYSTEROID DEHYDROGENASE DELTA(5)-DELTA(4) ISOMERASE AND DIFFERENTIAL EXPRESSION IN GONADS, ADRENAL-GLANDS, LIVER, AND KIDNEYS OF BOTH SEXES [J].

BAIN, PA ;

YOO, M ;

CLARKE, T ;

HAMMOND, SH ;

PAYNE, AH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (20) :8870-8874

[2] ENZYME CHARACTERISTICS OF 2 DISTINCT FORMS OF MOUSE 3-BETA-HYDROXYSTEROID DEHYDROGENASE/DELTA-5-DELTA-4-ISOMERASE COMPLEMENTARY DEOXYRIBONUCLEIC ACIDS EXPRESSED IN COS-1 CELLS [J].

CLARKE, TR ;

BAIN, PA ;

SHA, LL ;

PAYNE, AH .

ENDOCRINOLOGY, 1993, 132 (05) :1971-1976

[3]

CLARKE TR, 1992, 74TH ANN M END SOC S, P426

[4] EXPRESSION OF STEROIDOGENIC ENZYMES IN THE BOVINE PLACENTA AND FETAL ADRENAL-GLANDS THROUGHOUT GESTATION [J].

CONLEY, AJ ;

HEAD, JR ;

STIRLING, DT ;

MASON, JL .

ENDOCRINOLOGY, 1992, 130 (05) :2641-2650

[5]

COUET J, 1992, 9TH P INT C END NIC, P508

[6]

DELAUNOIT Y, 1992, J BIOL CHEM, V267, P4513

[7] 3-BETA-HYDROXYSTEROID ISOMERASE DEHYDROGENASE IN GUINEA-PIG KIDNEY - POSSIBLE INVOLVEMENT IN 11-DEOXYCORTICOSTERONE FORMATION INSITU [J].

DEVINE, PL ;

KELLY, NS ;

ADAMS, JB .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1986, 25 (02) :265-270

[8] 3-BETA-HYDROXYSTEROID DEHYDROGENASE ISOMERASE IN THE FETAL ZONE AND NEOCORTEX OF THE HUMAN FETAL ADRENAL-GLAND [J].

DOODY, KM ;

CARR, BR ;

RAINEY, WE ;

BYRD, W ;

MURRY, BA ;

STRICKLER, RC ;

THOMAS, JL ;

MASON, JI .

ENDOCRINOLOGY, 1990, 126 (05) :2487-2492

[9] CHARACTERIZATION, EXPRESSION, AND IMMUNOHISTOCHEMICAL LOCALIZATION OF 3-BETA-HYDROXYSTEROID DEHYDROGENASE/DELTA-5-DELTA-4 ISOMERASE IN HUMAN SKIN [J].

DUMONT, M ;

LUUTHE, V ;

DUPONT, E ;

PELLETIER, G ;

LABRIE, F .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1992, 99 (04) :415-421

[10] KINETIC COMPARISON OF THE 3-BETA-HYDROXYSTEROID DEHYDROGENASE-ACTIVITY IN HUMAN-PLACENTA, CHORION LAEVE, AND OVARY [J].

GIBB, W ;

LAVOIE, JC ;

MORINGONTHIER, M .

CANADIAN JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY, 1985, 63 (03) :183-186

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