NOREPINEPHRINE EXCITATION OF CUTANEOUS NOCICEPTORS IN ADJUVANT-INDUCED INFLAMED RATS DOES NOT DEPEND ON SYMPATHETIC NEURONS

被引：20

作者：

SATO, J ^{[1
]}

SUZUKI, S ^{[1
]}

TAMURA, R ^{[1
]}

KUMAZAWA, T ^{[1
]}

机构：

[1] NAGOYA UNIV,ENVIRONM MED RES INST,DEPT NEURAL REGULAT,NAGOYA 46401,JAPAN

来源：

NEUROSCIENCE LETTERS | 1994年 / 177卷 / 1-2期

关键词：

CHRONIC INFLAMMATION; POLYMODAL RECEPTOR; SYMPATHETIC POST GANGLIONIC NEURON; GUANETHIDINE; ALPHA(2)-ADRENOCEPTOR; SYMPATHETICALLY MAINTAINED PAIN;

D O I：

10.1016/0304-3940(94)90063-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To test the contribution of sympathetic postganglionic neurons (SPGNs) to adrenergic excitation of cutaneous nociceptor activities in adjuvant-inflamed rats (AI rats), we studied the effects of norepinephrine (NE) in a group of sympathectomized AI rats. Sympathectomy was complete in 4-6 weeks by guanethidine (30-50 mg/kg). NE excited polymodal receptor units in the saphenous nerve at an incidence (25-30%) similar to that in AI rats, while CH-38083 blocked such excitation. These results show that alpha-adrenoceptors in SPGNs are not involved in the norepinephrine excitation of cutaneous nociceptors in AI rats.

引用

页码：135 / 138

页数：4

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