ANTIRHINOVIRUS STRUCTURE-ACTIVITY-RELATIONSHIPS OF 6-SUBSTITUTED-9-(4-METHYLBENZYL)-2-TRIFLUOROMETHYL-9H-PURINES

被引：9

作者：

KELLEY, JL ^{[1
]}

LINN, JA ^{[1
]}

SELWAY, JWT ^{[1
]}

机构：

[1] WELLCOME RES LABS,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 25卷 / 02期

关键词：

antiviral; benzylpurine; purine; rhinovirus; trifluoromethylpurine;

D O I：

10.1016/0223-5234(90)90021-T

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

To evaluate the effect of different 6-substituents on antirhinoviral activity, a series of 6-substituted-9-(4-methylbenzyl)-2-trifluoromethyl-9H-purines was synthesized and tested. A matrix map of space adjacent to the 6-position was constructed to facilitate structure-activity analysis. This study provided evidence that a lipophilic pocket exists on the virus capsid surface, which accomodates the methyl group of the 6-methylaminopurines. © 1990.

引用

页码：131 / 135

页数：5

共 8 条

[1] IRREVERSIBLE ENZYME INHIBITORS .121. THYMIDINE PHOSPHORYLASE .9. ON NATURE AND DIMENSIONS OF HYDROPHOBIC BONDING REGION [J].