PNEUMOCOCCAL ANTICAPSULAR ANTIBODIES IN PATIENTS WITH CHRONIC CARDIOVASCULAR AND OBSTRUCTIVE LUNG-DISEASE IN THE NETHERLANDS

被引：10

作者：

BRUYN, GAW ^{[1
]}

HIEMSTRA, PS ^{[1
]}

MATZEVANDERLANS, A ^{[1
]}

VANFURTH, R ^{[1
]}

机构：

[1] UNIV HOSP LEIDEN,DEPT INFECT DIS,POB 9600,2300 RC LEIDEN,NETHERLANDS

来源：

JOURNAL OF INFECTIOUS DISEASES | 1990年 / 162卷 / 05期

关键词：

D O I：

10.1093/infdis/162.5.1192

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Differences in pneumococcal anticapsular antibody concentrations were assessed among patients with various chronic disorders and among young (25–35 years of age) and older adults (55–65 years). Antibody concentrations were determined by ELISA, using the whole 23-valent pneumococcal polysaccharide vaccine as antigen. No differences in mean or distribution of serum antibody concentrations were found among young adults (either healthy or asthmatic) or among older adults (healthy or with chronic obstructive pulmonary or chronic cardiovascular disease). Each group included individuals with low antibody levels. Therefore, the enhanced susceptibility to pneumococcal infections reported for some groups at risk, that is, elderly individuals and patients with chronic obstructive pulmonary or chronic cardiovascular disease, cannot be attributed solely to low anticapsular antibody concentrations. © 1990, by The University of Chicago.

引用

页码：1192 / 1194

页数：3

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