LOSS OF HETEROZYGOSITY FOR 10Q LOCI IN HUMAN GLIOMAS

被引：130

作者：

RASHEED, BKA

FULLER, GN

FRIEDMAN, AH

BIGNER, DD

BIGNER, SH

机构：

[1] DUKE UNIV,MED CTR,DEPT PATHOL,DIV NEUROSURG,BOX 3712,DURHAM,NC 27710

[2] DUKE UNIV,MED CTR,PREUSS BRAIN TUMOR RES LABS,DURHAM,NC 27710

来源：

GENES CHROMOSOMES & CANCER | 1992年 / 5卷 / 01期

关键词：

D O I：

10.1002/gcc.2870050111

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic and RFLP studies have shown that chromosome 10 is frequently lost in tumor cells from glioblastomas, suggesting that a suppressor gene important in tumorigenesis is present on this chromosome. Forty-one tumors were examined for loss of heterozygosity at 23 loci on chromosome 10 to determine the smallest common deletion interval on this chromosome. Seven tumors did not lose heterozygosity for any of the markers. Twenty-three tumors lost an allele for all the informative loci. In 11 tumors heterozygosity was maintained at some loci and lost at other loci, indicating partial deletion of chromosome 10. The common region of deletion in these 11 tumors was located in 10q24-q26 between the markers pHUK-8 and pMCT 122.2.

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页码：75 / 82

页数：8

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