SELECTION OF A PRECORE MUTANT OF HEPATITIS-B VIRUS AND REACTIVATION OF CHRONIC HEPATITIS-B ACQUIRED IN CHILDHOOD

被引：13

作者：

BORTOLOTTI, F

CRIVELLARO, C

BRUNETTO, MR

CADROBBI, P

BERTOLINI, A

ALBERTI, A

机构：

[1] PADUA HOSP, DEPT INFECT DIS, PADUA, ITALY

[2] LE MOLINETTE HOSP, DEPT GASTROENTEROL, TURIN, ITALY

来源：

JOURNAL OF PEDIATRICS | 1993年 / 123卷 / 04期

关键词：

D O I：

10.1016/S0022-3476(05)80956-4

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A 14-year-old girl with chronic hepatitis B had seroconversion from hepatitis B e antigen to antibody and achieved biochemical remission after 2 years. The disease reactivated 9 years later when a precore mutant had become the prevalent hepatitis B virus strain in serum. These results suggest that selection of a precore mutant might induce reactivation during adult life of chronic hepatitis B acquired in childhood, thus worsening the prognosis.

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收藏

页码：583 / 585

页数：3

相关论文

共 11 条

[1] LIVER-CIRRHOSIS ASSOCIATED WITH CHRONIC HEPATITIS-B VIRUS-INFECTION IN CHILDHOOD [J].

BORTOLOTTI, F ;

CALZIA, R ;

CADROBBI, P ;

GIACCHINI, R ;

CIRAVEGNA, B ;

ARMIGLIATO, M ;

PISCOPO, R ;

REALDI, G .

JOURNAL OF PEDIATRICS, 1986, 108 (02) :224-227

[2] LONG-TERM OUTCOME OF CHRONIC TYPE-B HEPATITIS IN PATIENTS WHO ACQUIRE HEPATITIS-B VIRUS-INFECTION IN CHILDHOOD [J].

BORTOLOTTI, F ;

CADROBBI, P ;

CRIVELLARO, C ;

GUIDO, M ;

RUGGE, M ;

NOVENTA, F ;

CALZIA, R ;

REALDI, G .

GASTROENTEROLOGY, 1990, 99 (03) :805-810

[3] WILD-TYPE AND E-ANTIGEN-MINUS HEPATITIS-B VIRUSES AND COURSE OF CHRONIC HEPATITIS [J].

BRUNETTO, MR ;

GIARIN, MM ;

OLIVERI, F ;

CHIABERGE, E ;

BALDI, M ;

ALFARANO, A ;

SERRA, A ;

SARACCO, G ;

VERME, G ;

WILL, H ;

BONINO, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (10) :4186-4190

[4]

BRUNETTO MR, 1989, ITAL J GASTROENTEROL, V21, P151

[5]

BRUNETTO MR, 1991, J HEPATOL S4, V13, pS84

[6]

CARMAN WF, 1989, LANCET, V2, P588

[7]

CHANG MH, 1988, HEPATOLOGY, V8, P375

[8] PRECORE MUTANT HEPATITIS-B VIRUS-INFECTION AND LIVER-DISEASE [J].

NAOUMOV, NV ;

SCHNEIDER, R ;

GROTZINGER, T ;

JUNG, MC ;

MISKA, S ;

PAPE, GR ;

WILL, H .

GASTROENTEROLOGY, 1992, 102 (02) :538-543

[9] HEPATITIS B-VIRUSES WITH PRECORE REGION DEFECTS PREVAIL IN PERSISTENTLY INFECTED HOSTS ALONG WITH SEROCONVERSION TO THE ANTIBODY AGAINST E-ANTIGEN [J].

OKAMOTO, H ;

YOTSUMOTO, S ;

AKAHANE, Y ;

YAMANAKA, T ;

MIYAZAKI, Y ;

SUGAI, Y ;

TSUDA, F ;

TANAKA, T ;

MIYAKAWA, Y ;

MAYUMI, M .

JOURNAL OF VIROLOGY, 1990, 64 (03) :1298-1303

[10] SEROLOGICAL AND HISTOLOGICAL FOLLOW UP OF CHRONIC HEPATITIS-B INFECTION [J].

RUIZMORENO, M ;

CAMPS, T ;

AGUADO, JG ;

PORRES, JC ;

OLIVA, H ;

BARTOLOME, J ;

CARRENO, V .

ARCHIVES OF DISEASE IN CHILDHOOD, 1989, 64 (08) :1165-1169