SYNERGISTIC EFFECTS BETWEEN AMOXICILLIN, METRONIDAZOLE, AND THE HYDROXYMETABOLITE OF METRONIDAZOLE AGAINST ACTINOBACILLUS-ACTINOMYCETEMCOMITANS

被引：50

作者：

PAVICIC, MJAMP ^{[1
]}

VANWINKELHOFF, AJ ^{[1
]}

DEGRAAFF, J ^{[1
]}

机构：

[1] ACAD CTR DENT AMSTERDAM,DEPT ORAL MICROBIOL,VAN DER BOECHORSTSTR 7,1081 BT AMSTERDAM,NETHERLANDS

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 05期

关键词：

D O I：

10.1128/AAC.35.5.961

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Interactions between metronidazole and amoxicillin, metronidazole and its hydroxymetabolite, and amoxicillin and the hydroxymetabolite of metronidazole were investigated with checkerboard titrations in combination with accurately determined MICs and MBCs. Actinobacillus actinomycetemcomitans was used as the test organism. Synergism was found for all three combinations. Fractional inhibitory concentration indices and fractional bactericidal concentration indices varied from 0.3 to 0.7. These synergistic interactions between these antibiotics may explain the efficacy of the combination of metronidazole and amoxicillin in various bacterial infections, including periodontal disease.

引用

页码：961 / 966

页数：6

共 31 条

[1] CAMPYLOBACTER-PYLORI - THERAPY REVIEW [J].