DIFFERENTIAL EFFECT OF CALCIUM AND BAY K-8644 ON THE INHIBITORY-ACTION OF ESTROGENS IN THE RAT UTERUS

被引:24
作者
FERNANDEZ, AI [1 ]
MARTINEZ, V [1 ]
CANTABRANA, B [1 ]
HIDALGO, A [1 ]
机构
[1] UNIV OVIEDO, FAC MED,DEPT MED,FARMACOL LAB, C JULIAN CLAVERIA S-N, E-33006 OVIEDO, SPAIN
来源
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1992年 / 23卷 / 03期
关键词
D O I
10.1016/0306-3623(92)90126-5
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. The effects of the estrogens estradiol (E2, 10(-7) to 3 x 10(-5) M) and diethylstilbestrol (DES, 10(-7) to 3 x 10(-6) M) on tonic contractions of the rat uterus induced by KCl and CaCl2 have been studied. 2. E2 and DES relaxed, in a dose-dependent way, the tonic contraction induced by KCl (60 mM) (IC50: 5.16 +/- 1.49 x 10(-6) and 4.51 +/- 0.03 x 10(-7) M); the tonic contraction induced by CaCl2 (3 mM) in the rat uterus incubated in depolarizing Krebs (127 mM of K+) have also been relaxed (IC50: 8.6 +/- 0.03 x 10(-7) and 2.56 +/- 0.07 x 10 M) by both drugs. 3. The CaCl2 (0.1 to 10 mM) counteracted the relaxing effect of E2 and DES, respectively, up to 28.13 +/- 10.2% and 34.71 +/- 11.5%, on KCl-induced contractions, and up to 126.36 +/- 19.35% and 95.8 +/- 16.3% on CaCl2-induced contractions. 4. Bay K 8644 (10(-10) to 10(-6) M) reversed the relaxing effect of E2 and DES, respectively, up to 42.49 +/- 2.28% and 43.31 +/- 3.59% on KCl-induced contractions, and up to 21.73 +/- 4.16% and 75.97 +/- 9.63% on CaCl2-induced contractions. 5. Propranolol (10(-6) M) did not modify the relaxing effect of E2 or DES on CaCl2-induced contractions.
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页码:549 / 554
页数:6
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