THE EXPRESSION OF PARATHYROID HORMONE-RELATED PROTEIN IN HUMAN BREAST-CANCER WITH SKELETAL METASTASES

被引：36

作者：

KOHNO, N

KITAZAWA, S

FUKASE, M

SAKODA, Y

KANBARA, Y

FURUYA, Y

OHASHI, O

ISHIKAWA, Y

SAITOH, Y

机构：

[1] The Department of Surgery, Hyogo Medical Center for Adults, Akashi, 651

[2] The Second Department of Pathology, Kobe University School of Medicine, Kobe, 650, Kusunoki-cho 7-5-2, Chuo-ku

[3] The Third Division of Internal Medicine, Kobe University School of Medicine, Kobe, 650, Kusunoki-cho 7-5-2, Chuo-ku

[4] The First Department of Surgery, Kobe University School of Medicine, Kobe, 650, Kusunoki-cho 7-5-2, Chuo-ku

来源：

SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY | 1994年 / 24卷 / 03期

关键词：

PARATHYROID HORMONE-RELATED PROTEIN; BREAST CANCER; SKELETAL METASTASES;

D O I：

10.1007/BF02032890

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The relationship between the expression of parathyroid hormone-related protein (PTHrP) by breast cancer and skeletal metastases, was investigated using a monoclonal antibody against human PTHrP (4B3). The immunohistochemical localization of PTHrP was studied in sections of formalin-fixed, paraffin-embeded tissues from 28 breast cancers obtained surgically between 1980 and 1985. Of the 28 patients, 12 developed skeletal metastases, 8 developed lung metastases, and the other 8 were alive and disease-free at the time of this study. Sixteen of the 28 (57%) tumors showed positive immunoreactivity to 4B3, the PTHrP positive ratio being 83% in the patients who developed skeletal metastases, 38% in those who developed lung metastases, and 38% in those without recurrence, respectively. Thus, a significantly higher proportion of the patients who developed skeletal metastases were positive for PTHrP than the other two groups (P < 0.05). Furthermore, the level of positive staining was strongly related to positivity for estrogen and progesterone receptors (P < 0.01). These results are consistent with the hypothesis that PTHrP might be necessary for metastases to erode bone and grow in skeletal sites, and its expression could be related to certain hormones.

引用

页码：215 / 220

页数：6

共 22 条

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