TAXANES FROM TAXUS-BACCATA

被引:61
作者
APPENDINO, G
GARIBOLDI, P
PISETTA, A
BOMBARDELLI, E
GABETTA, B
机构
[1] INDENA SPA,I-20141 MILAN,ITALY
[2] INVERNI BEFFA SPA,RIC & SVILUPPO LAB,I-20141 MILAN,ITALY
[3] DIPARTIMENTO SCI CHIM,I-62032 CAMERINO,ITALY
关键词
TAXUS-BACCATA; TAXACEAE; DITERPENOIDS; TAXANES; TAXICIN-I AND TAXICIN-II DIESTERS;
D O I
10.1016/0031-9422(92)80454-M
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A winter collection of yew needles gave two pairs of taxicin-I and taxicin-II diesters, the structures of which were established by spectral data and chemical reactions. The mixture of these diesters might correspond to the so-called 'desdimethylaminotaxine' of the old literature on yew. A detailed NMR analysis of the diesters allowed an unambiguous assignment of all H-1 and C-13 NMR resonances of these and related taxane derivatives.
引用
收藏
页码:4253 / 4257
页数:5
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