COMPUTER-ASSISTED DESIGN OF CHIRAL BORON ENOLATES - A NOVEL, HIGHLY ENANTIOSELECTIVE ALDOL REACTION FOR THIOACETATES AND THIOPROPIONATES

被引：43

作者：

GENNARI, C

MORESCA, D

VIETH, S

VULPETTI, A

机构：

[1] Dipartimento di Chimica Organica e Industriale, Università di Milano, Centro CNR per lo Studio dells Sostanze Organiche Naturali, Milano, I‐20133

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1993年 / 32卷 / 11期

关键词：

D O I：

10.1002/anie.199316181

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Unsubstituted and anti aldol products with excellent diastereo‐ and enantioselectivity are formed when enolates, generated from the corresponding thioacetates and thiopropionates by using bromoborane 1 and triethylamine, are treated with aldehydes. Bromoborane 1 was designed based on transition state computer modeling and then synthesized. (Figure Presented.) Copyright © 1993 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：1618 / 1621

页数：4

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