REACTIONS OF FORSKOLIN, A BIOLOGICALLY-ACTIVE DITERPENOID FROM COLEUS-FORSKOHLII

被引：73

作者：

BHAT, SV

BAJWA, BS

DORNAUER, H

DESOUZA, NJ

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1982年 / 03期

关键词：

D O I：

10.1039/p19820000767

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Forskolin (7.beta.-acetoxy-8,13-epoxy-1.alpha.,6.beta.,9.alpha.-trihydroxylabd-14-en-11-one), the major diterpenoid of C. forskohlii, has potent positive inotropic, antihypertensive and adenylate cyclase stimulant properties. The reactivity of its various functional groups (1.alpha.-OH, 6.beta.-OH, the derived 7.beta.-OH, 9.alpha.-OH, 11-oxo and 14,15-double bond) was studied through acylation, alkylation, dehydration, oxidation and reduction reactions.

引用

页码：767 / 771

页数：5

共 20 条

[1] BHAT SV, 1977, TETRAHEDRON LETT, P1669, DOI 10.1016/S0040-4039(01)93245-9
[2] THE CHEMISTRY OF THE TRITERPENES AND RELATED COMPOUNDS .18. ELUCIDATION OF THE STRUCTURE OF POLYPORENIC ACID-C
BOWERS, A
HALSALL, TG
JONES, ERH
LEMIN, AJ
[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1953, (SEP): : 2548 - 2560
[3] MASS SPECTROMETRY IN STRUCTURAL AND STEREOCHEMICAL PROBLEMS .1. STEROID KETONES
BUDZIKIEWICZ, H
DJERASSI, C
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1962, 84 (08) : 1430 - &
[4] COLLINS JC, 1968, TETRAHEDRON LETT, P3363
[5] THE CONVERSION OF HECOGENIN ACETATE INTO 11-OXOTIGOGENIN ACETATE
CORNFORTH, JW
OSBOND, JM
PHILLIPPS, GH
[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1954, (MAR): : 907 - 912
[6] ON STEROIDS .40. REDUCTION OF STEROIDAL KETONES WITH LITHIUM TRI-TERT-BUTOXYALUMINOHYDRIDE
FAJKOS, J
[J]. COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1959, 24 (07) : 2284 - 2290
[7] FRIED J, 1965, TETRAHEDRON LETT, P849
[8] GLC METHOD FOR ASSAY OF FORSKOLIN, A NOVEL POSITIVE INOTROPIC AND BLOOD PRESSURE-LOWERING AGENT
INAMDAR, PK
DORNAUER, H
DESOUZA, NJ
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1980, 69 (12) : 1449 - 1457
[9] EXPERIMENTS DIRECTED TOWARD TOTAL SYNTHESIS OF TERPENES. .6. STEREOCHEMISTRY OF ISOPIMARIC ACID
IRELAND, RE
NEWBOULD, J
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1963, 28 (01) : 23 - &
[10] REACTIONS OF ALPHA-KETOLS AND OTHER 21-HYDROXY STEROIDS WITH PHOSGENE .4. FORMATION OF 20-CHLORO-17,20-CYCLIC CARBONATES FROM 17ALPHA-HYDROXY-20-ONES
LEWBART, ML
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (01) : 78 - 84

← 1 2 →