EFFECTS OF LOCUS-CERULEUS LESIONS ON THE RELEASE OF ENDOGENOUS DOPAMINE IN THE RAT NUCLEUS-ACCUMBENS AND CAUDATE-NUCLEUS AS DETERMINED BY INTRACEREBRAL MICRODIALYSIS

被引：119

作者：

LATEGAN, AJ

MARIEN, MR

COLPAERT, FC

机构：

[1] Neurobiology Division, FONDAX-Groupe de Recherche SERVIER, Puteaux

来源：

BRAIN RESEARCH | 1990年 / 523卷 / 01期

关键词：

(+)-Amphetamine; 6-Hydroxydopamine; Caudate nucleus; Dopamine release; Intracerebral microdialysis; Locus ceruleus; Nucleus accumbens;

D O I：

10.1016/0006-8993(90)91646-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bilateral 6-hydroxydopamine lesions of the rat locus coeruleus (a) depleted forebrain norepinephrine levels by 67%, (b) reduced the basal release of dopamine in the nucleus accumbens and caudate nucleus by 26% and 19%, respectively, and (c) reduced (+)-amphetamine-induced release in the nucleus accumbens nucleus. The locus coeruleus appears to exert a tonic excitatory influence on striatal and limbic dopamine release in vivo. © 1990.

引用

收藏

页码：134 / 138

页数：5

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