CLONING AND CHARACTERIZATION OF A HUMAN CDNA (INPPL1) SHARING HOMOLOGY WITH INOSITOL POLYPHOSPHATE PHOSPHATASES

被引：39

作者：

HEJNA, JA ^{[1
]}

SAITO, H ^{[1
]}

MERKENS, LS ^{[1
]}

TITTLE, TV ^{[1
]}

JAKOBS, PM ^{[1
]}

WHITNEY, MA ^{[1
]}

GROMPE, M ^{[1
]}

FRIEDBERG, AS ^{[1
]}

MOSES, RE ^{[1
]}

机构：

[1] OREGON HLTH SCI UNIV,DEPT MED & MOLEC GENET,PORTLAND,OR 97201

来源：

GENOMICS | 1995年 / 29卷 / 01期

关键词：

D O I：

10.1006/geno.1995.1247

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have cloned a novel human cDNA, INPPL1 (GenBank Accession No. L36818), which maps to 11q23. The corresponding mRNA is 4657 nt in length and is widely expressed in both fetal and adult tissues. An open reading frame of 3441 nt encodes a putative polypeptide that shares several domains with inositol triphosphate phosphatases. Several polymorphisms have been mapped to the 3'-untranslated region, yet the putative coding region showed no polymorphisms in nine independent cDNA samples. (C) 1995 Academic Press, Inc.

引用

页码：285 / 287

页数：3

共 13 条

[1] THE LOWE OCULOCEREBRORENAL SYNDROME GENE ENCODES A PROTEIN HIGHLY HOMOLOGOUS TO INOSITOL POLYPHOSPHATE-5-PHOSPHATASE [J].

ATTREE, O ;

OLIVOS, IM ;

OKABE, I ;

BAILEY, LC ;

NELSON, DL ;

LEWIS, RA ;

MCINNES, RR ;

NUSSBAUM, RL .

NATURE, 1992, 358 (6383) :239-242

[2]

BROWN T, 1994, CURRENT PROTOCOLS MO

[3] SCANNING DETECTION OF MUTATIONS IN HUMAN ORNITHINE TRANSCARBAMOYLASE BY CHEMICAL MISMATCH CLEAVAGE [J].

GROMPE, M ;

MUZNY, DM ;

CASKEY, CT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (15) :5888-5892

[4] SPECIFIC ENZYMATIC AMPLIFICATION OF DNA INVITRO - THE POLYMERASE CHAIN-REACTION [J].

MULLIS, K ;

FALOONA, F ;

SCHARF, S ;

SAIKI, R ;

HORN, G ;

ERLICH, H .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1986, 51 :263-273

[5] REGULATION OF SIMIAN-VIRUS 40 TRANSCRIPTION - SENSITIVE ANALYSIS OF THE RNA SPECIES PRESENT EARLY IN INFECTIONS BY VIRUS OR VIRAL-DNA [J].

PARKER, BA ;

STARK, GR .

JOURNAL OF VIROLOGY, 1979, 31 (02) :360-369

[6]

ROSS TS, 1991, J BIOL CHEM, V266, P20283

[7]

Sambrook J., 1989, MOL CLONING LAB MANU

[8] LAMBDA-ZAP - A BACTERIOPHAGE LAMBDA-EXPRESSION VECTOR WITH INVIVO EXCISION PROPERTIES [J].

SHORT, JM ;

FERNANDEZ, JM ;

SORGE, JA ;

HUSE, WD .

NUCLEIC ACIDS RESEARCH, 1988, 16 (15) :7583-7600

[9]

SLATKO BE, 1994, CURRENT PROTOCOLS MO

[10] DETECTION OF SPECIFIC SEQUENCES AMONG DNA FRAGMENTS SEPARATED BY GEL-ELECTROPHORESIS [J].

SOUTHERN, EM .

JOURNAL OF MOLECULAR BIOLOGY, 1975, 98 (03) :503-+

← 1 2 →