ATHEROSCLEROTIC PLAQUE CAPS ARE LOCALLY WEAKENED WHEN MACROPHAGES DENSITY IS INCREASED

被引：423

作者：

LENDON, CL

DAVIES, MJ

BORN, GVR

RICHARDSON, PD

机构：

[1] UNIV LONDON ST GEORGES HOSP,SCH MED,CARDIOVASC PATHOL UNIT,CRANMER TERRACE,LONDON SW17 0RE,ENGLAND

[2] UNIV LONDON KINGS COLL,DEPT PHARMACOL,LONDON WC2R 2LS,ENGLAND

[3] BROWN UNIV,DIV BIOL & MED,PROVIDENCE,RI 02912

[4] BROWN UNIV,DIV ENGN,PROVIDENCE,RI 02912

来源：

ATHEROSCLEROSIS | 1991年 / 87卷 / 01期

关键词：

PLAQUE ULCERATION; PLAQUE RUPTURE; MONOCYTE DENSITY; MECHANICAL PROPERTIES;

D O I：

10.1016/0021-9150(91)90235-U

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The density of macrophages, identified by the antibody EBMII, in human aortic plaque caps was counted. A contiguous strip of cap tissue was tested mechanically. Aortic plaque caps which had undergone rupture (ulceration) at one end (n = 18) were compared with caps of intact plaques (n = 22). The caps of ruptured plaques showed a significant increase in macrophage density, an increased extensibility and decreased maximum stress (force per unit area) at fracture when compared with caps from intact plaques.

引用

页码：87 / 90

页数：4

共 21 条

[1] ANGIOGRAPHIC MORPHOLOGY AND THE PATHOGENESIS OF UNSTABLE ANGINA-PECTORIS [J].