INCREASED URINE HISTAMINE AND METHYLHISTAMINE IN INTERSTITIAL CYSTITIS

被引:85
作者
ELMANSOURY, M
BOUCHER, W
SANT, GR
THEOHARIDES, TC
机构
[1] TUFTS UNIV,NEW ENGLAND MED CTR,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BOSTON,MA 02111
[2] TUFTS UNIV,NEW ENGLAND MED CTR,SCH MED,DEPT UROL,BOSTON,MA 02111
关键词
BLADDER DISEASES; CYSTITIS; MAST CELLS; HISTAMINE; METHYLHISTAMINES;
D O I
10.1016/S0022-5347(17)32737-4
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Interstitial cystitis is a painful bladder disorder occurring mostly in women, and is presently diagnosed by clinical presentation, as well as the presence of mucosal glomerulations and inflammation on bladder distention. An increased number of bladder mast cells have been implicated in the pathophysiology of interstitial cystitis but previous reports of spot urine histamine have not confirmed bladder mast cell activation. The availability of easily measurable objective criteria could make the diagnosis easier. Histamine and its major metabolite, methylhistamine, were measured in spot and 24-hour urine specimens from a number of normal female volunteers, control patients and interstitial cystitis patients. In interstitial cystitis patients the histamine levels were only slightly increased in the spot (p <0.01) and 24-hour urine (p <0.03) collections. Methylhistamine, on the other hand, was greatly elevated in spot (p <10(-10)) and 24-hour (p <0.0008) urine samples. These results indicate that methylhistamine levels could serve as useful diagnostic end points for interstitial cystitis.
引用
收藏
页码:350 / 353
页数:4
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