IPRIFLAVONE DIRECTLY INHIBITS OSTEOCLASTIC ACTIVITY

被引：29

作者：

ALBANESE, CV

CUDD, A

ARGENTINO, L

ZAMBONINZALLONE, A

MACINTYRE, L

机构：

[1] UNIV LONDON ST BARTHOLOMEWS HOSP & MED COLL, WILLIAM HARVEY RES INST, LONDON EC1M 6BQ, ENGLAND

[2] UNIV BARI, SCH MED, INST HUMAN ANAT, I-70100 BARI, ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 199卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.1318

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ipriflavone, an isoflavone derivative, is a new drug used in an attempt to decrease bone loss in osteoporosis. Experimental studies have shown that this compound acts by inhibiting osteoclastic bone resorption both in vivo and in vitro, but the mechanism of its inhibitory action on resorbing cells remains unclear. Using bone resorption assays, video image analysis together with measurements of intracellular free calcium in isolated osteoclasts, we show here that IP directly inhibits osteoclastic activity by the modulation of intracellular free calcium. (C) 1994 Academic Press, Inc.

引用

页码：930 / 936

页数：7

共 21 条

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