NONSPECIFIC SYSTEMIC IMMUNE SUPPRESSION INDUCED BY PHOTODYNAMIC TREATMENT OF LYMPH-NODE CELLS WITH BACTERIOCHLORIN-A

被引：14

作者：

VANIPEREN, HP ^{[1
]}

SCHUITMAKER, HJ ^{[1
]}

VANHENEGOUWEN, GMJB ^{[1
]}

机构：

[1] ACAD HOSP LEIDEN,DEPT OPHTHALMOL LAB,LEIDEN,NETHERLANDS

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 1995年 / 28卷 / 03期

关键词：

PHOTODYNAMIC THERAPY; BACTERIOCHLORIN A; CONTACT HYPERSENSITIVITY; PHOTOIMMUNOLOGY;

D O I：

10.1016/1011-1344(95)07116-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although photodynamic therapy is being used increasingly for the treatment of cancer, its effect on immune responses has received little attention. This aspect was studied in a rat model. Rats were given (intravenously) lymph node cells which were simultaneously exposed to a photosensitizer and light. As a result of this treatment the animals showed a decreased contact hypersensitivity response. Most important is that the generated immunosuppression proved to be non-specific. The consequence of this finding may be that photodynamic therapy of tumours can inhibit the immune response against malignant cells.

引用

页码：197 / 202

页数：6

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